DOI: 10.1084/jem.172.6.1701. OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

10.1084/jem.172.6.1701

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

Congenitally athymic rats injected with CD45RBhigh CD4+ T cells from congenic euthymic donors developed a severe wasting disease with inflammatory infiltrates in liver, lung, stomach, thyroid, and pancreas. In contrast, recipients of CD45RBlow CD4+ T cells remained well and continued to gain weight. Animals given unfractionated CD4+ T cells, i.e., a mixture of approximately two-thirds CD45RBhigh and one-third CD45RBlow, were protected from the wasting disease, and the incidence of organ-specific inflammation was much reduced compared with that found in recipients of CD45RBhigh cells alone. The data suggest that this latter subset of CD4+ T cells has autoaggressive potential that is inhibited in normal animals by cells of the CD45RBlow CD4+ phenotype. The possible consequences of a breakdown in this immunoregulatory mechanism are briefly discussed.

Bibliography

Powrie, F., & Mason, D. (1990). OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset. The Journal of Experimental Medicine, 172(6), 1701â1708.

Authors 2

F Powrie (first)
D Mason (additional)

References 0 Referenced 296

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 9:50 p.m.)
Indexed	1 month ago (July 30, 2025, 10:50 a.m.)
Issued	34 years, 9 months ago (Dec. 1, 1990)
Published	34 years, 9 months ago (Dec. 1, 1990)
Published Online	34 years, 9 months ago (Dec. 1, 1990)
Published Print	34 years, 9 months ago (Dec. 1, 1990)

Funders 0

None

BibTeX

@article{Powrie_1990, title={OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.}, volume={172}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.172.6.1701}, DOI={10.1084/jem.172.6.1701}, number={6}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Powrie, F and Mason, D}, year={1990}, month=dec, pages={1701–1708} }

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