DOI: 10.1084/jem.171.2.439. The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis.

The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis.

10.1084/jem.171.2.439

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

Cytokines mediate many host responses to bacterial infections. We determined the inflammatory activities of five cytokines in the central nervous system: TNF-alpha, IL-1 alpha, IL-1 beta, macrophage inflammatory protein 1 (MIP-1), and macrophage inflammatory protein 2 (MIP-2). Using a rabbit model of meningeal inflammation, each cytokine (except IL-1 beta) induced enhanced blood brain barrier permeability, leukocytosis in cerebrospinal fluid, and brain edema. Homologous antibodies to each mediator inhibited leukocytosis and brain edema, and moderately decreased blood brain barrier permeability. In rabbits treated with anti-CD-18 antibody to render neutrophils dysfunctional for adhesion, each cytokine studied lost the ability to cause leukocytosis and brain edema. After intracisternal challenge with pneumococci, antibodies to TNF or IL-1 prevented inflammation, while anti-MIP-1 or anti-MIP-2 caused only a 2-h delay in the onset of inflammation. We suggest these cytokines have multiple inflammatory activities in the central nervous system and contribute to tissue damage during pneumococcal meningitis.

Authors 7

K Saukkonen (first)
S Sande (additional)
C Cioffe (additional)
S Wolpe (additional)
B Sherry (additional)
A Cerami (additional)
E Tuomanen (additional)

References 0 Referenced 261

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 9:39 p.m.)
Indexed	2 days, 19 hours ago (Aug. 30, 2025, 1:14 p.m.)
Issued	35 years, 7 months ago (Feb. 1, 1990)
Published	35 years, 7 months ago (Feb. 1, 1990)
Published Online	35 years, 7 months ago (Feb. 1, 1990)
Published Print	35 years, 7 months ago (Feb. 1, 1990)

Funders 0

None

BibTeX

@article{Saukkonen_1990, title={The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis.}, volume={171}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.171.2.439}, DOI={10.1084/jem.171.2.439}, number={2}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Saukkonen, K and Sande, S and Cioffe, C and Wolpe, S and Sherry, B and Cerami, A and Tuomanen, E}, year={1990}, month=feb, pages={439–448} }

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