DOI: 10.1084/jem.170.3.991. Xenogeneic skin graft rejection is especially dependent on CD4+ T cells.

Xenogeneic skin graft rejection is especially dependent on CD4+ T cells.

10.1084/jem.170.3.991

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

B6 mice were treated in vivo with anti-CD4, anti-CD8, or both anti-T cell antibodies together in an effort to prolong xenogeneic compared with allogeneic skin graft survival. Mice treated with anti-CD4 antibody showed prolonged survival of xenogeneic monkey or rabbit skin even after they had rejected whole MHC-disparate allogeneic mouse skin. Furthermore, the addition of cyclosporine was synergistic with the anti-CD4 antibody in prolonging graft survival. These results suggest that the cell-mediated response to xenogeneic antigens is especially dependent on CD4+ lymphocytes, a feature shared by the response to allogeneic minor histocompatibility antigens. In addition, the results suggest a possible approach to clinical immunosuppression for some forms of xenogeneic transplantation.

Bibliography

Pierson, R. N., Winn, H. J., Russell, P. S., & Auchincloss, H. (1989). Xenogeneic skin graft rejection is especially dependent on CD4+ T cells. The Journal of Experimental Medicine, 170(3), 991â996.

Authors 4

R N Pierson (first)
H J Winn (additional)
P S Russell (additional)
H Auchincloss (additional)

References 0 Referenced 180

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 9:37 p.m.)
Indexed	2 months, 3 weeks ago (June 11, 2025, 7:30 p.m.)
Issued	36 years ago (Sept. 1, 1989)
Published	36 years ago (Sept. 1, 1989)
Published Online	36 years ago (Sept. 1, 1989)
Published Print	36 years ago (Sept. 1, 1989)

Funders 0

None

BibTeX

@article{Pierson_1989, title={Xenogeneic skin graft rejection is especially dependent on CD4+ T cells.}, volume={170}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.170.3.991}, DOI={10.1084/jem.170.3.991}, number={3}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Pierson, R N and Winn, H J and Russell, P S and Auchincloss, H}, year={1989}, month=sep, pages={991–996} }

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