Abstract
The Pgp-1 glycoprotein (Ly-24 antigen) is acquired by mature murine T lymphocytes at the time of primary antigen stimulation Pgp-1 was previously shown to be a useful cell surface marker for distinguishing antigen-specific memory CD8+ T lymphocytes after immunization. Here we demonstrate that this observation extends to CD4+ T lymphocytes. Antigen-specific CD4+ T cells in mice immunized with sperm whale myoglobin or keyhole limpet hemocyanin were contained nearly exclusively in the minor Pgp-1+ subset.
Dates
Type | When |
---|---|
Created | 21 years, 2 months ago (June 24, 2004, 3:56 a.m.) |
Deposited | 2 years, 1 month ago (July 24, 2023, 9:30 p.m.) |
Indexed | 5 months ago (March 30, 2025, 12:04 p.m.) |
Issued | 36 years, 5 months ago (April 1, 1989) |
Published | 36 years, 5 months ago (April 1, 1989) |
Published Online | 36 years, 5 months ago (April 1, 1989) |
Published Print | 36 years, 5 months ago (April 1, 1989) |
@article{Butterfield_1989, title={A subset of memory CD4+ helper T lymphocytes identified by expression of Pgp-1.}, volume={169}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.169.4.1461}, DOI={10.1084/jem.169.4.1461}, number={4}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Butterfield, K and Fathman, C G and Budd, R C}, year={1989}, month=apr, pages={1461–1466} }