DOI: 10.1084/jem.169.3.795. Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

10.1084/jem.169.3.795

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

Transgenic mice that carry on a large fraction of their T cells an alpha/beta T cell receptor that recognizes the male antigen in the context of H-2Db molecules were constructed. An mAb specific for the transgenic receptor was developed and used to analyze T cell subsets in male transgenic H-2b mice. The vast majority of immature CD4+8+ T cells that express the transgenic TCR were deleted in the male transgenic mouse. Nevertheless, the majority of T cells spared by this deletion process expressed a high level of the transgenic TCR. These T cells, however, had an abnormal CD4/CD8 phenotype in that they expressed either no CD8 molecules or only low levels.

Bibliography

Teh, H. S., Kishi, H., Scott, B., & Von Boehmer, H. (1989). Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules. The Journal of Experimental Medicine, 169(3), 795â806.

Authors 4

H S Teh (first)
H Kishi (additional)
B Scott (additional)
H Von Boehmer (additional)

References 0 Referenced 162

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 9:29 p.m.)
Indexed	5 months ago (March 31, 2025, 12:26 a.m.)
Issued	36 years, 6 months ago (March 1, 1989)
Published	36 years, 6 months ago (March 1, 1989)
Published Online	36 years, 6 months ago (March 1, 1989)
Published Print	36 years, 6 months ago (March 1, 1989)

Funders 0

None

BibTeX

@article{Teh_1989, title={Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.}, volume={169}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.169.3.795}, DOI={10.1084/jem.169.3.795}, number={3}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Teh, H S and Kishi, H and Scott, B and Von Boehmer, H}, year={1989}, month=mar, pages={795–806} }

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