DOI: 10.1084/jem.167.6.1895. Granulocyte elastase cleaves human high molecular weight kininogen and destroys its clot-promoting activity.

Granulocyte elastase cleaves human high molecular weight kininogen and destroys its clot-promoting activity.

10.1084/jem.167.6.1895

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

Purified human granulocyte elastase cleaved purified human high molecular weight (HMW) kininogen into multiple low molecular weight fragments, and destroyed the clot-promoting activity of the HMW kininogen. Elastase digestion did not release kinin or destroy the bradykinin portion of the HMW kininogen molecule; kallikrein could release kinin from the elastase-induced low molecular weight digestion products of HMW kininogen. Purified alpha 1-antitrypsin prevented the destruction of the clot-promoting activity of HMW kininogen by elastase; it also delayed the clotting of normal plasma. Elastase may play a significant role in altered hemostasis as well as fibrinolysis, in areas of inflammation to which polymorphonuclear leukocytes have been attracted.

Bibliography

Kleniewski, J., & Donaldson, V. (1988). Granulocyte elastase cleaves human high molecular weight kininogen and destroys its clot-promoting activity. The Journal of Experimental Medicine, 167(6), 1895â1907.

Authors 2

J Kleniewski (first)
V Donaldson (additional)

References 0 Referenced 24

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 9:19 p.m.)
Indexed	4 months, 2 weeks ago (April 6, 2025, 9:03 a.m.)
Issued	37 years, 2 months ago (June 1, 1988)
Published	37 years, 2 months ago (June 1, 1988)
Published Online	37 years, 2 months ago (June 1, 1988)
Published Print	37 years, 2 months ago (June 1, 1988)

Funders 0

None

BibTeX

@article{Kleniewski_1988, title={Granulocyte elastase cleaves human high molecular weight kininogen and destroys its clot-promoting activity.}, volume={167}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.167.6.1895}, DOI={10.1084/jem.167.6.1895}, number={6}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Kleniewski, J and Donaldson, V}, year={1988}, month=jun, pages={1895–1907} }

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