DOI: 10.1084/jem.166.4.991. Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

10.1084/jem.166.4.991

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

The immunoregulatory effects of transforming growth factor beta (TGF-beta) and recombinant murine tumor necrosis factor alpha (rMuTNF-alpha) on CTL generation and activity were examined. The results demonstrate that TGF-beta, in a dose-dependent manner, inhibited CTL generation but not CTL activity. The inhibitory effects were detected only when TGF-beta was added within the first 48 h of the MLC. Little activity was seen when it was added thereafter, including the addition of TGF-beta to the cytotoxicity assay. The production of TNF-alpha, which occurs during early phases of the MLC and which is inhibited in the presence of TGF-beta, appears to have an important regulatory role, as altering the levels of TNF-alpha in an MLC can significantly influence CTL development. The inhibitory effects of TGF-beta on the MLC can be significantly reversed by the addition of rMuTNF-alpha to the cultures. These results demonstrate that TGF-beta can inhibit MLC and subsequent CTL generation at early stages of the reaction, and such inhibition may involve the suppression of TNF-alpha production.

Bibliography

Ranges, G. E., Figari, I. S., Espevik, T., & Palladino, M. A. (1987). Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha. The Journal of Experimental Medicine, 166(4), 991â998.

Authors 4

G E Ranges (first)
I S Figari (additional)
T Espevik (additional)
M A Palladino (additional)

References 0 Referenced 363

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 9:12 p.m.)
Indexed	1 month ago (July 26, 2025, 4:57 a.m.)
Issued	37 years, 10 months ago (Oct. 1, 1987)
Published	37 years, 10 months ago (Oct. 1, 1987)
Published Online	37 years, 10 months ago (Oct. 1, 1987)
Published Print	37 years, 10 months ago (Oct. 1, 1987)

Funders 0

None

BibTeX

@article{Ranges_1987, title={Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.}, volume={166}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.166.4.991}, DOI={10.1084/jem.166.4.991}, number={4}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Ranges, G E and Figari, I S and Espevik, T and Palladino, M A}, year={1987}, month=oct, pages={991–998} }

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