DOI: 10.1084/jem.164.5.1397. HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes.

HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes.

10.1084/jem.164.5.1397

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

Human influenza A virus-specific, cytotoxic T cells have been shown previously to recognize the virus nucleoprotein on infected cells. CTL preparations from four HLA B37-positive donors were shown to recognize a synthetic peptide that corresponded to amino acids 335-349 of the nucleoprotein sequence. Influenza-specific CTL from 10 donors of other HLA types failed to recognize this epitope. CD8+ CTL lines were derived from lymphocytes of two HLA B37-positive donors and used to show that the peptide was represented on virus-infected cells and to determine the probable boundaries of the epitope.

Bibliography

McMichael, A. J., Gotch, F. M., & Rothbard, J. (1986). HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes. The Journal of Experimental Medicine, 164(5), 1397â1406.

Authors 3

A J McMichael (first)
F M Gotch (additional)
J Rothbard (additional)

References 0 Referenced 66

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 9:03 p.m.)
Indexed	1 year ago (Aug. 9, 2024, 7:33 p.m.)
Issued	38 years, 10 months ago (Nov. 1, 1986)
Published	38 years, 10 months ago (Nov. 1, 1986)
Published Online	38 years, 10 months ago (Nov. 1, 1986)
Published Print	38 years, 10 months ago (Nov. 1, 1986)

Funders 0

None

BibTeX

@article{McMichael_1986, title={HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes.}, volume={164}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.164.5.1397}, DOI={10.1084/jem.164.5.1397}, number={5}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={McMichael, A J and Gotch, F M and Rothbard, J}, year={1986}, month=nov, pages={1397–1406} }

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