DOI: 10.1084/jem.154.6.1957. Detection of the human T cell lymphoma virus p19 in cells of some patients with cutaneous T cell lymphoma and leukemia using a monoclonal antibody.

Detection of the human T cell lymphoma virus p19 in cells of some patients with cutaneous T cell lymphoma and leukemia using a monoclonal antibody.

10.1084/jem.154.6.1957

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

A monoclonal antibody specific for the internal p19 protein of a type-C retrovirus (HTLV) isolated from human neoplastic T cells has been developed. Its specificity has been shown by radioimmune precipitation and by affinity chromatography of iodinated HTLV proteins. By indirect immune fluorescence this antibody recognizes only HTLV-producing cells. Examination of cells from patients with cutaneous T cell lymphomas and leukemias and with other types of lymphomas and leukemias indicated that HTLV p19 expression is rare. The monoclonal antibody will be useful in determining the natural reservoir of HTLV, possibly in a subset of mature T cell neoplasias.

Bibliography

Robert-Guroff, M., Ruscetti, F. W., Posner, L. E., Poiesz, B. J., & Gallo, R. C. (1981). Detection of the human T cell lymphoma virus p19 in cells of some patients with cutaneous T cell lymphoma and leukemia using a monoclonal antibody. The Journal of Experimental Medicine, 154(6), 1957â1964.

Authors 5

M Robert-Guroff (first)
F W Ruscetti (additional)
L E Posner (additional)
B J Poiesz (additional)
R C Gallo (additional)

References 0 Referenced 186

None

Dates

Type	When
Created	21 years, 2 months ago (June 23, 2004, 5 p.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 8:24 p.m.)
Indexed	4 months, 3 weeks ago (April 8, 2025, 10:18 p.m.)
Issued	43 years, 9 months ago (Dec. 1, 1981)
Published	43 years, 9 months ago (Dec. 1, 1981)
Published Online	43 years, 9 months ago (Dec. 1, 1981)
Published Print	43 years, 9 months ago (Dec. 1, 1981)

Funders 0

None

BibTeX

@article{Robert_Guroff_1981, title={Detection of the human T cell lymphoma virus p19 in cells of some patients with cutaneous T cell lymphoma and leukemia using a monoclonal antibody.}, volume={154}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.154.6.1957}, DOI={10.1084/jem.154.6.1957}, number={6}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Robert-Guroff, M and Ruscetti, F W and Posner, L E and Poiesz, B J and Gallo, R C}, year={1981}, month=dec, pages={1957–1964} }

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