DOI: 10.1084/jem.153.3.694. Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.

Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.

10.1084/jem.153.3.694

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

The antiphosphocholine (PC) antibody in normal mouse sera (NMS) provides protection against intravenous infection with encapsulated strain WU2 of type 3 Streptococcus pneumoniae. Mice unable to make anti-PC antibody, as a result of suppression with anti-T-15 idiotype or inheritance of the xid gene of CAB/N mice, are highly susceptible to infection with strain WU2. Mice inheriting the xid gene can be protected with NMS from immunologically normal mice or with IgM hybridoma anti-PC antibody. The protective effect of NMS can be removed with PC-containing immunoabsorbents.

Bibliography

Briles, D. E., Nahm, M., Schroer, K., Davie, J., Baker, P., Kearney, J., & Barletta, R. (1981). Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae. The Journal of Experimental Medicine, 153(3), 694â705.

Authors 7

D E Briles (first)
M Nahm (additional)
K Schroer (additional)
J Davie (additional)
P Baker (additional)
J Kearney (additional)
R Barletta (additional)

References 0 Referenced 371

None

Dates

Type	When
Created	21 years, 2 months ago (June 23, 2004, 5 p.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 8:14 p.m.)
Indexed	2 months ago (July 4, 2025, 7:48 a.m.)
Issued	44 years, 6 months ago (March 1, 1981)
Published	44 years, 6 months ago (March 1, 1981)
Published Online	44 years, 6 months ago (March 1, 1981)
Published Print	44 years, 6 months ago (March 1, 1981)

Funders 0

None

BibTeX

@article{Briles_1981, title={Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.}, volume={153}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.153.3.694}, DOI={10.1084/jem.153.3.694}, number={3}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Briles, D E and Nahm, M and Schroer, K and Davie, J and Baker, P and Kearney, J and Barletta, R}, year={1981}, month=mar, pages={694–705} }

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