DOI: 10.1084/jem.140.6.1547. PROTECTIVE AND CELLULAR IMMUNE RESPONSES TO IDIOTYPIC DETERMINANTS ON CELLS FROM A SPONTANEOUS LYMPHOMA OF NZB/NZW F1 MICE

PROTECTIVE AND CELLULAR IMMUNE RESPONSES TO IDIOTYPIC DETERMINANTS ON CELLS FROM A SPONTANEOUS LYMPHOMA OF NZB/NZW F1 MICE

10.1084/jem.140.6.1547

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

A spontaneous lymphoma (141) producing monoclonal IgM is established in NZB/NZW F1 (B/W) mice who spontaneously develop an autoimmune disease. Idiotypic determinants of 141 IgM are present on the lymphoma cell surface as shown by indirect immunofluorescence and specific cytotoxicity with rabbit anti-idiotypic antiserum. Fluorescence and cytotoxicity are inhibited by 141 IgM but not by 104E IgM, a monoclonal IgM produced by a BALB/c plasmacytoma. Immunization of B/W mice with 141 IgM before transplantation of lymphoma 141 confers protective immunity. No such protection occurs after immunization with 104E IgM or other unrelated proteins. Protected mice contain spleen cells cytotoxic for 141 lymphoma cells. This cytotoxicity is blocked by incubation of spleen cells with 141 IgM but not with 104E IgM. Moreover, splenic lymphocytes from protected mice are stimulated to synthesize DNA by 141 IgM but not by 104E IgM. These results suggest that specific cellular immune responses to idiotypic determinants may participate in the observed protection against challenge with the corresponding B-cell tumor.

Bibliography

Sugai, S., Palmer, D. W., Talal, N., & Witz, I. P. (1974). PROTECTIVE AND CELLULAR IMMUNE RESPONSES TO IDIOTYPIC DETERMINANTS ON CELLS FROM A SPONTANEOUS LYMPHOMA OF NZB/NZW F1 MICE. The Journal of Experimental Medicine, 140(6), 1547â1558.

Authors 4

Susumu Sugai (first)
Donald W. Palmer (additional)
Norman Talal (additional)
Isaac P. Witz (additional)

References 0 Referenced 57

None

Dates

Type	When
Created	21 years, 2 months ago (June 23, 2004, 7:23 p.m.)
Deposited	2 years, 1 month ago (July 29, 2023, 7:06 p.m.)
Indexed	23 minutes ago (Sept. 4, 2025, 3:20 a.m.)
Issued	50 years, 9 months ago (Dec. 1, 1974)
Published	50 years, 9 months ago (Dec. 1, 1974)
Published Online	50 years, 9 months ago (Dec. 1, 1974)
Published Print	50 years, 9 months ago (Dec. 1, 1974)

Funders 0

None

BibTeX

@article{Sugai_1974, title={PROTECTIVE AND CELLULAR IMMUNE RESPONSES TO IDIOTYPIC DETERMINANTS ON CELLS FROM A SPONTANEOUS LYMPHOMA OF NZB/NZW F1 MICE}, volume={140}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.140.6.1547}, DOI={10.1084/jem.140.6.1547}, number={6}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Sugai, Susumu and Palmer, Donald W. and Talal, Norman and Witz, Isaac P.}, year={1974}, month=dec, pages={1547–1558} }

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