DOI: 10.1084/jem.140.5.1364. EFFECTS OF CONCANAVALIN A ON MOUSE PERITONEAL MACROPHAGES

EFFECTS OF CONCANAVALIN A ON MOUSE PERITONEAL MACROPHAGES

10.1084/jem.140.5.1364

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Concanavalin A (Con A) binds to saccharide residues on the mouse peritoneal macrophage plasma membrane and stimulates extensive pinocytic interiorization of the membrane. The overall pinocytic rate is increased 3.5–4.5 times by the addition of Con A, and the surface marker enzyme adenosine triphosphatase can be identified histochemically in association with the cytoplasmic vesicles generated after exposure of the cells to Con A. Once formed, these pinocytic vesicles may persist for several days and fail to show morphologic evidence of fusion with primary or preformed secondary lysosomes. There is no apparent effect on the capacity of the macrophage to ingest either latex particles or IgG-coated SRBC administered either simultaneously with or subsequent to the Con A.

Bibliography

Edelson, P. J., & Cohn, Z. A. (1974). EFFECTS OF CONCANAVALIN A ON MOUSE PERITONEAL MACROPHAGES. The Journal of Experimental Medicine, 140(5), 1364â1386.

Authors 2

Paul J. Edelson (first)
Zanvil A. Cohn (additional)

References 0 Referenced 152

None

Dates

Type	When
Created	21 years, 2 months ago (June 23, 2004, 7:23 p.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 6:32 p.m.)
Indexed	1 year, 1 month ago (June 29, 2024, 12:33 a.m.)
Issued	50 years, 9 months ago (Nov. 1, 1974)
Published	50 years, 9 months ago (Nov. 1, 1974)
Published Online	50 years, 9 months ago (Nov. 1, 1974)
Published Print	50 years, 9 months ago (Nov. 1, 1974)

Funders 0

None

BibTeX

@article{Edelson_1974, title={EFFECTS OF CONCANAVALIN A ON MOUSE PERITONEAL MACROPHAGES}, volume={140}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.140.5.1364}, DOI={10.1084/jem.140.5.1364}, number={5}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Edelson, Paul J. and Cohn, Zanvil A.}, year={1974}, month=nov, pages={1364–1386} }

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