DOI: 10.1084/jem.140.3.797. DIRECT EVIDENCE FOR HAGEMAN FACTOR (FACTOR XII) ACTIVATION BY BACTERIAL LIPOPOLYSACCHARIDES (ENDOTOXINS)

DIRECT EVIDENCE FOR HAGEMAN FACTOR (FACTOR XII) ACTIVATION BY BACTERIAL LIPOPOLYSACCHARIDES (ENDOTOXINS)

10.1084/jem.140.3.797

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Purified precursor Hageman factor has been demonstrated to bind to soluble bacterial lipopolysaccharide (LPS, endotoxin) isolated from Escherichia coli 0111:B4, and this complex has been shown to have the capacity to convert prekallikrein to its active form. In addition, LPS-activated Hageman factor substantially reduces clotting times in XII-deficient plasma. The capacity to activate Hageman factor has been demonstrated to reside in the lipid A region of the LPS molecule. Activation of Hageman factor by LPS contrasts with fluid-phase activation (e.g., by kallikrein or trypsin) in that no cleavage to lower molecular weight fragments occurs. High concentrations of LPS inhibit the activity of Hageman factor, probably by a direct LPS-Hageman factor interaction.

Bibliography

Morrison, D. C., & Cochrane, C. G. (1974). DIRECT EVIDENCE FOR HAGEMAN FACTOR (FACTOR XII) ACTIVATION BY BACTERIAL LIPOPOLYSACCHARIDES (ENDOTOXINS). The Journal of Experimental Medicine, 140(3), 797â811.

Authors 2

David C. Morrison (first)
Charles G. Cochrane (additional)

References 0 Referenced 185

None

Dates

Type	When
Created	21 years, 2 months ago (June 23, 2004, 7:23 p.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 6:26 p.m.)
Indexed	2 weeks, 5 days ago (Aug. 7, 2025, 4:49 p.m.)
Issued	50 years, 11 months ago (Sept. 1, 1974)
Published	50 years, 11 months ago (Sept. 1, 1974)
Published Online	50 years, 11 months ago (Sept. 1, 1974)
Published Print	50 years, 11 months ago (Sept. 1, 1974)

Funders 0

None

BibTeX

@article{Morrison_1974, title={DIRECT EVIDENCE FOR HAGEMAN FACTOR (FACTOR XII) ACTIVATION BY BACTERIAL LIPOPOLYSACCHARIDES (ENDOTOXINS)}, volume={140}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.140.3.797}, DOI={10.1084/jem.140.3.797}, number={3}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Morrison, David C. and Cochrane, Charles G.}, year={1974}, month=sep, pages={797–811} }

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