DOI: 10.1084/jem.138.5.1194. FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES

FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES

10.1084/jem.138.5.1194

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Antigen activation of DNA synthesis in immune thymus-derived lymphocytes of guinea pigs requires the cooperation of macrophages and lymphocytes. We have investigated the role of histocompatibility determinants in this macrophage-lymphocyte interaction using cells from inbred strain 2 and 13 guinea pigs. The data demonstrate that efficient presentation of macrophage-associated antigen to the lymphocyte requires identity between macrophage and lymphocyte at some portion of the major histocompatibility complex. The failure of allogeneic macrophages to effectively initiate immune lymphocyte proliferation was not the result of the presence of an inhibitor of blastogenesis released in mixtures of allogeneic cells, peculiarities of the antigen or lymphoid cells employed, nor differing kinetics of activation by allogeneic macrophages. In addition, data were presented that demonstrated that alloantisera inhibit lymphocyte DNA synthesis by functional interference with macrophage-lymphocyte interaction.

Bibliography

Rosenthal, A. S., & Shevach, E. M. (1973). FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES. The Journal of Experimental Medicine, 138(5), 1194â1212.

Authors 2

Alan S. Rosenthal (first)
Ethan M. Shevach (additional)

References 0 Referenced 758

None

Dates

Type	When
Created	21 years, 2 months ago (June 23, 2004, 7:23 p.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 5:11 p.m.)
Indexed	2 days, 22 hours ago (Aug. 27, 2025, 12:28 p.m.)
Issued	51 years, 9 months ago (Nov. 1, 1973)
Published	51 years, 9 months ago (Nov. 1, 1973)
Published Online	51 years, 9 months ago (Nov. 1, 1973)
Published Print	51 years, 9 months ago (Nov. 1, 1973)

Funders 0

None

BibTeX

@article{Rosenthal_1973, title={FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES}, volume={138}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.138.5.1194}, DOI={10.1084/jem.138.5.1194}, number={5}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Rosenthal, Alan S. and Shevach, Ethan M.}, year={1973}, month=nov, pages={1194–1212} }

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