DOI: 10.1084/jem.137.2.451. FORMATION AND FUNCTION OF A COMPLEX OF THE C3 PROACTIVATOR WITH A PROTEIN FROM COBRA VENOM

FORMATION AND FUNCTION OF A COMPLEX OF THE C3 PROACTIVATOR WITH A PROTEIN FROM COBRA VENOM

10.1084/jem.137.2.451

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

The role of C3 proactivator (C3PA) and a factor isolated from cobra venom (CoF) in the formation of a principle able to cleave C3 was investigated. The results clearly demonstrate two modes of interaction of C3PA with CoF. In isolated form, C3PA and CoF were found to form a reversible protein-protein complex in free solution. This complex had some C3 cleaving activity. In the presence of minute amounts of a partially purified normal serum substance, factor D, the C3PA-CoF complex was stabilized and its efficiency in cleaving C3 was greatly increased. Factor D is thus an activator of C3PA. A firm complex composed of C3PA and CoF, and possessing C3 cleaving activity, was also formed by addition of CoF to serum.

Bibliography

Cooper, N. R. (1973). FORMATION AND FUNCTION OF A COMPLEX OF THE C3 PROACTIVATOR WITH A PROTEIN FROM COBRA VENOM. The Journal of Experimental Medicine, 137(2), 451â460.

Authors 1

Neil R. Cooper (first)

References 0 Referenced 51

None

Dates

Type	When
Created	21 years, 2 months ago (June 23, 2004, 7:23 p.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 5:05 p.m.)
Indexed	1 year, 7 months ago (Jan. 14, 2024, 10:57 a.m.)
Issued	52 years, 7 months ago (Feb. 1, 1973)
Published	52 years, 7 months ago (Feb. 1, 1973)
Published Online	52 years, 7 months ago (Feb. 1, 1973)
Published Print	52 years, 7 months ago (Feb. 1, 1973)

Funders 0

None

BibTeX

@article{Cooper_1973, title={FORMATION AND FUNCTION OF A COMPLEX OF THE C3 PROACTIVATOR WITH A PROTEIN FROM COBRA VENOM}, volume={137}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.137.2.451}, DOI={10.1084/jem.137.2.451}, number={2}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Cooper, Neil R.}, year={1973}, month=feb, pages={451–460} }

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