DOI: 10.1084/jem.135.4.938. SEROLOGICALLY DEMONSTRABLE ALLOANTIGENS OF MOUSE EPIDERMAL CELLS

SEROLOGICALLY DEMONSTRABLE ALLOANTIGENS OF MOUSE EPIDERMAL CELLS

10.1084/jem.135.4.938

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Single cells were prepared from mouse tail epidermis by a method which gives high viability counts and so permits their use in cytotoxicity tests. According to tests with standard alloantisera, the antigen phenotype of mouse epidermal cells is H-2+θ+Sk+H-Y+TL-Ly-A-Ly-B,C-PC-. The skin differentiation alloantigen Sk, which is responsible for homograft reactions directed selectively against skin, is expressed also on brain, but not on other cell types; it is present on the transplanted neuroblastoma C1300. Cytotoxicity tests with epidermal cells of H-2 congenic mouse stocks confirm that the Sk locus is not closely linked to H-2. The lymphoid cell differentiation antigen θ also is present on both epidermal cells and brain. Mice frequently retain θ-incompatible or Sk-incompatible skin grafts although they have formed substantial titers of θ or Sk antibody in response to grafting. Male (H-Y) antigen is demonstrable on epidermal cells by cytotoxicity tests with H-Y antibody, as it is also on one other type of cell, spermatozoa.

Bibliography

Scheid, M., Boyse, E. A., Carswell, E. A., & Old, L. J. (1972). SEROLOGICALLY DEMONSTRABLE ALLOANTIGENS OF MOUSE EPIDERMAL CELLS. The Journal of Experimental Medicine, 135(4), 938â955.

Authors 4

Margrit Scheid (first)
Edward A. Boyse (additional)
Elizabeth A. Carswell (additional)
Lloyd J. Old (additional)

References 0 Referenced 221

None

Dates

Type	When
Created	21 years, 2 months ago (June 23, 2004, 7:23 p.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 4:53 p.m.)
Indexed	4 months, 3 weeks ago (April 8, 2025, 9:58 p.m.)
Issued	53 years, 5 months ago (April 1, 1972)
Published	53 years, 5 months ago (April 1, 1972)
Published Online	53 years, 5 months ago (April 1, 1972)
Published Print	53 years, 5 months ago (April 1, 1972)

Funders 0

None

BibTeX

@article{Scheid_1972, title={SEROLOGICALLY DEMONSTRABLE ALLOANTIGENS OF MOUSE EPIDERMAL CELLS}, volume={135}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.135.4.938}, DOI={10.1084/jem.135.4.938}, number={4}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Scheid, Margrit and Boyse, Edward A. and Carswell, Elizabeth A. and Old, Lloyd J.}, year={1972}, month=apr, pages={938–955} }

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