DOI: 10.1084/jem.127.3.455. CYTOLOGICAL EVIDENCE FOR A RELATIONSHIP BETWEEN NORMAL HEMATOPOIETIC COLONY-FORMING CELLS AND CELLS OF THE LYMPHOID SYSTEM

CYTOLOGICAL EVIDENCE FOR A RELATIONSHIP BETWEEN NORMAL HEMATOPOIETIC COLONY-FORMING CELLS AND CELLS OF THE LYMPHOID SYSTEM

10.1084/jem.127.3.455

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

The relationship between hematopoietic colony-forming stem cells and cells in the thymus and lymph nodes of unirradiated mice has been investigated using a chromosome-marker technique. It was found that a high proportion of cells in the thymus may belong to the same clone as normal hematopoietic colony-forming cells. It was also found that cells belonging to the same clone as colony-forming cells may reach the lymph nodes, and that nodes containing such cells can participate in an immunological response against sheep red cells. Either the precursors of cells in thymus and lymph node are identical with hematopoietic colony-forming cells, or they are both descendants of a common precursor which has not yet been identified. The results are compatible with the view that cells of the hematopoietic system and the immune system may be derived from the same stem cell.

Bibliography

Wu, A. M., Till, J. E., Siminovitch, L., & McCulloch, E. A. (1968). CYTOLOGICAL EVIDENCE FOR A RELATIONSHIP BETWEEN NORMAL HEMATOPOIETIC COLONY-FORMING CELLS AND CELLS OF THE LYMPHOID SYSTEM. The Journal of Experimental Medicine, 127(3), 455â464.

Authors 4

A. M. Wu (first)
J. E. Till (additional)
L. Siminovitch (additional)
E. A. McCulloch (additional)

References 0 Referenced 319

None

Dates

Type	When
Created	21 years, 2 months ago (June 23, 2004, 7:23 p.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 4:19 p.m.)
Indexed	20 hours, 58 minutes ago (Sept. 4, 2025, 9:52 a.m.)
Issued	57 years, 6 months ago (March 1, 1968)
Published	57 years, 6 months ago (March 1, 1968)
Published Online	57 years, 6 months ago (March 1, 1968)
Published Print	57 years, 6 months ago (March 1, 1968)

Funders 0

None

BibTeX

@article{Wu_1968, title={CYTOLOGICAL EVIDENCE FOR A RELATIONSHIP BETWEEN NORMAL HEMATOPOIETIC COLONY-FORMING CELLS AND CELLS OF THE LYMPHOID SYSTEM}, volume={127}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.127.3.455}, DOI={10.1084/jem.127.3.455}, number={3}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Wu, A. M. and Till, J. E. and Siminovitch, L. and McCulloch, E. A.}, year={1968}, month=mar, pages={455–464} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        4
      ]
    ],
    "date-time": "2025-09-04T13:52:37Z",
    "timestamp": 1756993957648
  },
  "reference-count": 0,
  "publisher": "Rockefeller University Press",
  "issue": "3",
  "content-domain": {
    "domain": [
      "rupress.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1968,
        3,
        1
      ]
    ]
  },
  "abstract": "<jats:p>The relationship between hematopoietic colony-forming stem cells and cells in the thymus and lymph nodes of unirradiated mice has been investigated using a chromosome-marker technique. It was found that a high proportion of cells in the thymus may belong to the same clone as normal hematopoietic colony-forming cells. It was also found that cells belonging to the same clone as colony-forming cells may reach the lymph nodes, and that nodes containing such cells can participate in an immunological response against sheep red cells. Either the precursors of cells in thymus and lymph node are identical with hematopoietic colony-forming cells, or they are both descendants of a common precursor which has not yet been identified. The results are compatible with the view that cells of the hematopoietic system and the immune system may be derived from the same stem cell.</jats:p>",
  "DOI": "10.1084/jem.127.3.455",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        6,
        23
      ]
    ],
    "date-time": "2004-06-23T23:23:31Z",
    "timestamp": 1088033011000
  },
  "page": "455-464",
  "update-policy": "http://dx.doi.org/10.1084/jem.crossmarkpolicy",
  "source": "Crossref",
  "is-referenced-by-count": 319,
  "title": "CYTOLOGICAL EVIDENCE FOR A RELATIONSHIP BETWEEN NORMAL HEMATOPOIETIC COLONY-FORMING CELLS AND CELLS OF THE LYMPHOID SYSTEM",
  "prefix": "10.1084",
  "volume": "127",
  "author": [
    {
      "given": "A. M.",
      "family": "Wu",
      "sequence": "first",
      "affiliation": [
        {
          "name": "From the Departments of Medicine and Medical Biophysics, University of Toronto, and The Ontario Cancer Institute, Toronto, Ontario, Canada"
        }
      ]
    },
    {
      "given": "J. E.",
      "family": "Till",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "From the Departments of Medicine and Medical Biophysics, University of Toronto, and The Ontario Cancer Institute, Toronto, Ontario, Canada"
        }
      ]
    },
    {
      "given": "L.",
      "family": "Siminovitch",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "From the Departments of Medicine and Medical Biophysics, University of Toronto, and The Ontario Cancer Institute, Toronto, Ontario, Canada"
        }
      ]
    },
    {
      "given": "E. A.",
      "family": "McCulloch",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "From the Departments of Medicine and Medical Biophysics, University of Toronto, and The Ontario Cancer Institute, Toronto, Ontario, Canada"
        }
      ]
    }
  ],
  "member": "291",
  "published-online": {
    "date-parts": [
      [
        1968,
        3,
        1
      ]
    ]
  },
  "container-title": "The Journal of Experimental Medicine",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://rupress.org/jem/article-pdf/127/3/455/1652506/455.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://rupress.org/jem/article-pdf/127/3/455/1652506/455.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        7,
        24
      ]
    ],
    "date-time": "2023-07-24T20:19:18Z",
    "timestamp": 1690229958000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://rupress.org/jem/article/127/3/455/5599/CYTOLOGICAL-EVIDENCE-FOR-A-RELATIONSHIP-BETWEEN"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1968,
        3,
        1
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          1968,
          3,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1084/jem.127.3.455",
  "relation": {},
  "ISSN": [
    "1540-9538",
    "0022-1007"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1968,
        3,
        1
      ]
    ]
  }
}