DOI: 10.1084/jem.118.6.1021. IMMUNOLOGICAL UNRESPONSIVENESS TO SENSITIZATION WITH SIMPLE CHEMICAL COMPOUNDS

IMMUNOLOGICAL UNRESPONSIVENESS TO SENSITIZATION WITH SIMPLE CHEMICAL COMPOUNDS

10.1084/jem.118.6.1021

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Guinea pigs fed picryl chloride to induce specific immunologic unresponsiveness cleared small amounts of venously infused antipicryl antibody at a rate equal to that of normal guinea pigs. Catabolism of passively administered picryl-specific antibody did not alter the unresponsive state of picryl chloride-fed guinea pigs or the responsive state of normal guinea pigs. Lymphoid cells of picryl chloride immunized guinea pigs produced equal amounts of picryl-specific antibody in picryl chloride-fed and normal animals. Allergen-fed guinea pigs remained unresponsive to attempted sensitization with the allergen in excess of 10 months after the final feeding, though some became feebly sensitive between 9 and 11 months. Second attempts to make unresponsive animals hypersensitive were unsuccessful. White blood cells of guinea pigs unresponsive to picryl chloride were unable to transfer delayed-type hypersensitivity for picryl chloride to normal recipients yet readily transferred tuberculin hypersensitivity.

Bibliography

Battisto, J. R., & Chase, M. W. (1963). IMMUNOLOGICAL UNRESPONSIVENESS TO SENSITIZATION WITH SIMPLE CHEMICAL COMPOUNDS. The Journal of Experimental Medicine, 118(6), 1021â1035.

Authors 2

Jack R. Battisto (first)
Merrill W. Chase (additional)

References 0 Referenced 26

None

Dates

Type	When
Created	21 years, 2 months ago (June 22, 2004, 4:51 p.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 3:35 p.m.)
Indexed	1 year, 9 months ago (Nov. 2, 2023, 9:48 a.m.)
Issued	61 years, 8 months ago (Dec. 1, 1963)
Published	61 years, 8 months ago (Dec. 1, 1963)
Published Online	61 years, 8 months ago (Dec. 1, 1963)
Published Print	61 years, 8 months ago (Dec. 1, 1963)

Funders 0

None

BibTeX

@article{Battisto_1963, title={IMMUNOLOGICAL UNRESPONSIVENESS TO SENSITIZATION WITH SIMPLE CHEMICAL COMPOUNDS}, volume={118}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.118.6.1021}, DOI={10.1084/jem.118.6.1021}, number={6}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Battisto, Jack R. and Chase, Merrill W.}, year={1963}, month=dec, pages={1021–1035} }

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