DOI: 10.1084/jem.118.2.307. STRUCTURE OF TYPE 5 ADENOVIRUS [Penn]

10.1084/jem.118.2.307

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Purified type 5 adenovirus was disrupted at pH 10.5 and the capsid shown to be comprised of two characteristic morphological subunits: (a) Hollow, polygonal structures corresponding to the virus capsomeres seen in preparation of purified virus and (b) thread-like strands also identifiable in preparations of purified virus. These structures were compared morphologically with purified preparations of the group- and type-specific soluble antigens characteristically produced in mammalian cells infected with adenoviruses. The group-specific soluble antigen was a homogeneous preparation of hollow, polygonal rods identical with the virus capsomeres. The type-specific soluble antigen corresponded to the thread- or fiber-like components of the purified virus particle. Inspection of disrupted virus preparations confirmed earlier immunological data which indicated that the major virus antigen was the group-specific soluble antigen. These data provide convincing evidence for the hypothesis that the adenovirus-induced soluble antigens represent virus subunits produced in excess.

Bibliography

Wilcox, W. C., Ginsberg, H. S., & Anderson, T. F. (1963). STRUCTURE OF TYPE 5 ADENOVIRUS. The Journal of Experimental Medicine, 118(2), 307â314.

Authors 3

Wesley C. Wilcox (first)
Harold S. Ginsberg (additional)
Thomas F. Anderson (additional)

References 0 Referenced 57

None

Dates

Type	When
Created	21 years, 2 months ago (June 22, 2004, 4:51 p.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 3:32 p.m.)
Indexed	1 year, 7 months ago (Jan. 11, 2024, 4:39 a.m.)
Issued	62 years ago (Aug. 1, 1963)
Published	62 years ago (Aug. 1, 1963)
Published Online	62 years ago (Aug. 1, 1963)
Published Print	62 years ago (Aug. 1, 1963)

Funders 0

None

BibTeX

@article{Wilcox_1963, title={STRUCTURE OF TYPE 5 ADENOVIRUS}, volume={118}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.118.2.307}, DOI={10.1084/jem.118.2.307}, number={2}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Wilcox, Wesley C. and Ginsberg, Harold S. and Anderson, Thomas F.}, year={1963}, month=aug, pages={307–314} }

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