DOI: 10.1083/jcb.96.3.679. Interactions between the receptors for platelet-derived growth factor and epidermal growth factor.

Interactions between the receptors for platelet-derived growth factor and epidermal growth factor.

10.1083/jcb.96.3.679

Crossref journal-article

Rockefeller University Press

The Journal of cell biology (291)

Abstract

Preincubation of Swiss 3T3 cells or human fibroblasts with purified platelet-derived growth factor (PDGF) at 4 degrees C or 37 degrees C rapidly inhibits subsequent binding of 125I-epidermal growth factor (125I-EGF). The effect does not result from competition by PDGF for binding to the EGF receptor since (a) very low concentrations of PDGF are effective, (b) cells with EGF receptors but no PDGF receptors are not affected, and (c) the inhibition persists even if the bound PDGF is eluted before incubating the cells with 125I-EGF. PDGF does not affect 125I-insulin binding nor does EGF affect 125I-PDGF binding under these conditions. Endothelial cell-derived growth factor also competes for binding to PDGF receptors and inhibits 125I-EGF binding. The inhibition demonstrated by PDGF seems to result from an increase in the Kd for 125I-EGF binding with no change in the number of EGF receptors.

Bibliography

Bowen-Pope, D. F., Dicorleto, P. E., & Ross, R. (1983). Interactions between the receptors for platelet-derived growth factor and epidermal growth factor. The Journal of Cell Biology, 96(3), 679â683.

Authors 3

D F Bowen-Pope (first)
P E Dicorleto (additional)
R Ross (additional)

References 0 Referenced 109

None

Dates

Type	When
Created	21 years, 3 months ago (May 14, 2004, 7:04 p.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 1:12 p.m.)
Indexed	3 months, 1 week ago (May 19, 2025, 8:07 a.m.)
Issued	42 years, 5 months ago (March 1, 1983)
Published	42 years, 5 months ago (March 1, 1983)
Published Online	42 years, 5 months ago (March 1, 1983)
Published Print	42 years, 5 months ago (March 1, 1983)

Funders 0

None

BibTeX

@article{Bowen_Pope_1983, title={Interactions between the receptors for platelet-derived growth factor and epidermal growth factor.}, volume={96}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.96.3.679}, DOI={10.1083/jcb.96.3.679}, number={3}, journal={The Journal of cell biology}, publisher={Rockefeller University Press}, author={Bowen-Pope, D F and Dicorleto, P E and Ross, R}, year={1983}, month=mar, pages={679–683} }

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