DOI: 10.1083/jcb.70.3.719. Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules.

Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules.

10.1083/jcb.70.3.719

Crossref journal-article

Rockefeller University Press

The Journal of cell biology (291)

Abstract

Cationic proteins purified from human polymorphonuclear leukocyte granules exert a cytotoxic effect on mammalian tumor cells. This effect is time and concentration dependent, is inhibited by the anionic agent heparin, and is enhanced by preheating the cationic proteins. Other strongly basic proteins (histone, protamine) also exhibited cytotoxic activity. Myeloperoxidase isolated from human leukocytes is cytotoxic when combined with H2O2 and chloride. Under these conditions, the potency of the myeloperoxidase-mediated system is greater than that of the cationic proteins.

Bibliography

Clark, R. A., Olsson, I., & Klebanoff, S. J. (1976). Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules. The Journal of Cell Biology, 70(3), 719â723.

Authors 3

R A Clark (first)
I Olsson (additional)
S J Klebanoff (additional)

References 0 Referenced 50

None

Dates

Type	When
Created	21 years, 3 months ago (May 14, 2004, 7:04 p.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 3:40 a.m.)
Indexed	1 year, 1 month ago (Aug. 1, 2024, 8:51 p.m.)
Issued	49 years ago (Sept. 1, 1976)
Published	49 years ago (Sept. 1, 1976)
Published Online	49 years ago (Sept. 1, 1976)
Published Print	49 years ago (Sept. 1, 1976)

Funders 0

None

BibTeX

@article{Clark_1976, title={Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules.}, volume={70}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.70.3.719}, DOI={10.1083/jcb.70.3.719}, number={3}, journal={The Journal of cell biology}, publisher={Rockefeller University Press}, author={Clark, R A and Olsson, I and Klebanoff, S J}, year={1976}, month=sep, pages={719–723} }

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