DOI: 10.1083/jcb.50.2.469. SULFATE METABOLISM IN PANCREATIC ACINAR CELLS

SULFATE METABOLISM IN PANCREATIC ACINAR CELLS

10.1083/jcb.50.2.469

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

The metabolism of inorganic sulfate in pancreatic acinar cells was studied by electron microscope radioautography in mice injected with sulfate-35S. Labeled sulfate was concentrated in the Golgi complex at 10 min. Within 30 min, much of the radioactive material had been transferred to condensing vacuoles. These were subsequently transformed into zymogen granules. By 4 hr after injection, some of the zymogen granules with radioactive contents were undergoing secretion, and labeled material was present in the pancreatic duct system. The Golgi complex in pancreatic acinar cells is known to be responsible for concentrating and packaging digestive enzymes delivered to it from the endoplasmic reticulum. Our work demonstrates that the Golgi complex in these cells is also engaged in the manufacture of sulfated materials, probably sulfated mucopolysaccharides, which are packaged along with the enzymes in zymogen granules and released with them into the pancreatic secretion.

Bibliography

Berg, N. B., & Young, R. W. (1971). SULFATE METABOLISM IN PANCREATIC ACINAR CELLS. The Journal of Cell Biology, 50(2), 469â483.

Authors 2

Norton B. Berg (first)
Richard W. Young (additional)

References 0 Referenced 54

None

Dates

Type	When
Created	21 years, 3 months ago (May 14, 2004, 6:01 p.m.)
Deposited	2 years, 1 month ago (July 23, 2023, 11:14 p.m.)
Indexed	11 months, 3 weeks ago (Sept. 5, 2024, 9:26 a.m.)
Issued	54 years ago (Aug. 1, 1971)
Published	54 years ago (Aug. 1, 1971)
Published Online	54 years ago (Aug. 1, 1971)
Published Print	54 years ago (Aug. 1, 1971)

Funders 0

None

BibTeX

@article{Berg_1971, title={SULFATE METABOLISM IN PANCREATIC ACINAR CELLS}, volume={50}, ISSN={0021-9525}, url={http://dx.doi.org/10.1083/jcb.50.2.469}, DOI={10.1083/jcb.50.2.469}, number={2}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Berg, Norton B. and Young, Richard W.}, year={1971}, month=aug, pages={469–483} }

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