DOI: 10.1083/jcb.46.1.42. IMMUNOGLOBULIN SYNTHESIS AND SECRETION

10.1083/jcb.46.1.42

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

This study was designed to determine the time in the intracellular life of immunoglobulin when the carbohydrate moieties are added. Plasma cells from a mouse myeloma tumor were exposed to glucosamine-3H (a "bridge" sugar), galactose-3H, or leucine-3H. With each of the above isotopes, the percentage of total radioactive immunoglobulin that has been secreted after different periods of labeling and the extent to which puromycin prevented incorporation into immunoglobulin were determined. The results indicate that both galactose and glucosamine (in its N-acetyl form) become covalently incorporated into immunoglobulin G late in its intracellular life and suggest that glucosamine is also added onto nascent polypeptide chains (i.e., on polyribosomes).

Bibliography

Schenkein, I., & Uhr, J. W. (1970). IMMUNOGLOBULIN SYNTHESIS AND SECRETION. The Journal of Cell Biology, 46(1), 42â51.

Authors 2

Isaac Schenkein (first)
Jonathan W. Uhr (additional)

References 0 Referenced 34

None

Dates

Type	When
Created	21 years, 3 months ago (May 14, 2004, 6:01 p.m.)
Deposited	2 years, 1 month ago (July 23, 2023, 10:47 p.m.)
Indexed	5 months ago (March 30, 2025, 9:33 p.m.)
Issued	55 years, 2 months ago (July 1, 1970)
Published	55 years, 2 months ago (July 1, 1970)
Published Online	55 years, 2 months ago (July 1, 1970)
Published Print	55 years, 2 months ago (July 1, 1970)

Funders 0

None

BibTeX

@article{Schenkein_1970, title={IMMUNOGLOBULIN SYNTHESIS AND SECRETION}, volume={46}, ISSN={0021-9525}, url={http://dx.doi.org/10.1083/jcb.46.1.42}, DOI={10.1083/jcb.46.1.42}, number={1}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Schenkein, Isaac and Uhr, Jonathan W.}, year={1970}, month=jul, pages={42–51} }

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