Abstract
Heavy metals may be incorporated from solution into tissue sections for electron microscopy. The resulting increase in density of the tissue provides greatly enhanced contrast with minimal distortion. Relative densities of various structures are found to depend on the heavy metal ions present and on the conditions of staining. Certain hitherto unobserved details are revealed and some sort of specificity exists, although the factors involved are not yet understood.
Dates
Type | When |
---|---|
Created | 21 years, 3 months ago (May 14, 2004, 1:40 p.m.) |
Deposited | 2 years ago (July 23, 2023, 9:50 p.m.) |
Indexed | 8 hours, 32 minutes ago (Aug. 21, 2025, 2:28 p.m.) |
Issued | 67 years ago (July 25, 1958) |
Published | 67 years ago (July 25, 1958) |
Published Online | 67 years ago (July 25, 1958) |
Published Print | 67 years ago (July 25, 1958) |
@article{Watson_1958, title={Staining of Tissue Sections for Electron Microscopy with Heavy Metals}, volume={4}, ISSN={0021-9525}, url={http://dx.doi.org/10.1083/jcb.4.4.475}, DOI={10.1083/jcb.4.4.475}, number={4}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Watson, Michael L.}, year={1958}, month=jul, pages={475–478} }