DOI: 10.1083/jcb.201605100. Reassessing the mechanics of parasite motility and host-cell invasion

Reassessing the mechanics of parasite motility and host-cell invasion

10.1083/jcb.201605100

Crossref journal-article

Rockefeller University Press

Journal of Cell Biology (291)

Abstract

The capacity to migrate is fundamental to multicellular and single-celled life. Apicomplexan parasites, an ancient protozoan clade that includes malaria parasites (Plasmodium) and Toxoplasma, achieve remarkable speeds of directional cell movement. This rapidity is achieved via a divergent actomyosin motor system, housed within a narrow compartment that lies underneath the length of the parasite plasma membrane. How this motor functions at a mechanistic level during motility and host cell invasion is a matter of debate. Here, we integrate old and new insights toward refining the current model for the function of this motor with the aim of revitalizing interest in the mechanics of how these deadly pathogens move.

Bibliography

Tardieux, I., & Baum, J. (2016). Reassessing the mechanics of parasite motility and host-cell invasion. Journal of Cell Biology, 214(5), 507â515.

Authors 2

Isabelle Tardieux (first)
Jake Baum (additional)

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Dates

Type	When
Created	9 years ago (Aug. 29, 2016, 9:18 a.m.)
Deposited	2 years, 1 month ago (July 23, 2023, 6:11 a.m.)
Indexed	3 weeks, 3 days ago (Aug. 6, 2025, 9:47 a.m.)
Issued	9 years ago (Aug. 29, 2016)
Published	9 years ago (Aug. 29, 2016)
Published Online	9 years ago (Aug. 29, 2016)
Published Print	9 years ago (Aug. 29, 2016)

Funders 3

Wellcome Trust 10.13039/100004440 Wellcome
Awards1
1. 100993/Z/13/Z
Fondation pour la Recherche Médicale 10.13039/501100002915
Region: Europe
pri (Trusts, charities, foundations (both public and private))
Labels2
1. Foundation for Medical Research
2. FRM
Awards1
1. FRM-DEQ20100318279
Fondation Innovations en Infectiologie 10.13039/100008656
Region: Europe
pri (Trusts, charities, foundations (both public and private))
Labels4
1. FINOVI Foundation
2. Fondation Finovi
3. Innovations in Infectiology Foundation
4. Finovi

BibTeX

@article{Tardieux_2016, title={Reassessing the mechanics of parasite motility and host-cell invasion}, volume={214}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.201605100}, DOI={10.1083/jcb.201605100}, number={5}, journal={Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Tardieux, Isabelle and Baum, Jake}, year={2016}, month=aug, pages={507–515} }

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