DOI: 10.1083/jcb.200503106. Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors

Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors

10.1083/jcb.200503106

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

Internalization of activated receptors regulates signaling, and endocytic adaptor proteins are well-characterized in clathrin-mediated uptake. One of these adaptor proteins, huntingtin interacting protein 1 (HIP1), induces cellular transformation and is overexpressed in some prostate cancers. We have discovered that HIP1 associates with the androgen receptor through a central coiled coil domain and is recruited to DNA response elements upon androgen stimulation. HIP1 is a novel androgen receptor regulator, significantly repressing transcription when knocked down using a silencing RNA approach and activating transcription when overexpressed. We have also identified a functional nuclear localization signal at the COOH terminus of HIP1, which contributes to the nuclear translocation of the protein. In conclusion, we have discovered that HIP1 is a nucleocytoplasmic protein capable of associating with membranes and DNA response elements and regulating transcription.

Bibliography

Mills, I. G., Gaughan, L., Robson, C., Ross, T., McCracken, S., Kelly, J., & Neal, D. E. (2005). Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors. The Journal of Cell Biology, 170(2), 191â200.

Authors 7

Ian G. Mills (first)
Luke Gaughan (additional)
Craig Robson (additional)
Theodora Ross (additional)
Stuart McCracken (additional)
John Kelly (additional)
David E. Neal (additional)

References 50 Referenced 59

10.1093/nar/25.17.3389 / Nucleic Acids Res. (1997)
10.1093/nar/gnh097 / Nucleic Acids Res. (2004)
10.1677/jme.0.0290041 / J. Mol. Endocrinol. (2002)
10.1074/jbc.274.25.17599 / J. Biol. Chem. (1999)
10.1074/jbc.M313703200 / J. Biol. Chem. (2004)
10.1038/nm972 / Nat. Med. (2004)
10.1093/embo-reports/kvd092 / EMBO Rep. (2000)
10.1080/08977190412331279908 / Growth Factors. (2004)
10.1083/jcb.147.7.1503 / J. Cell Biol. (1999)
10.1126/science.291.5506.1051 / Science. (2001)
10.1074/jbc.M103710200 / J. Biol. Chem. (2001)
10.1074/jbc.M203423200 / J. Biol. Chem. (2002)
10.1242/jcs.111.8.1031 / J. Cell Sci. (1998)
10.1021/bi0259150 / Biochemistry. (2002)
10.1073/pnas.93.21.11540 / Proc. Natl. Acad. Sci. USA. (1996)
10.1091/mbc.e04-06-0468 / Mol. Biol. Cell. (2004)
10.1083/jcb.122.3.635 / J. Cell Biol. (1993)
10.1083/jcb.149.3.537 / J. Cell Biol. (2000)
10.1074/jbc.M312645200 / J. Biol. Chem. (2004)
10.1038/ng0597-44 / Nat. Genet. (1997)
10.1002/j.1460-2075.1993.tb05947.x / EMBO J. (1993)
10.1074/jbc.M112310200 / J. Biol. Chem. (2002)
10.1074/jbc.M006598200 / J. Biol. Chem. (2001)
10.1073/pnas.94.11.5679 / Proc. Natl. Acad. Sci. USA. (1997)
10.1006/bbrc.1999.1776 / Biochem. Biophys. Res. Commun. (1999)
10.1074/jbc.C100401200 / J. Biol. Chem. (2001)
10.1016/S0092-8674(04)00117-5 / Cell. (2004)
10.1074/jbc.M108177200 / J. Biol. Chem. (2001)
10.1091/mbc.6.12.1721 / Mol. Biol. Cell. (1995)
10.1210/mend.14.10.0541 / Mol. Endocrinol. (2000)
10.1126/science.1092586 / Science. (2004)
10.1038/sj.emboj.7600445 / EMBO J. (2004)
10.1172/JCI0215529 / J. Clin. Invest. (2002)
10.1016/S0166-2236(99)01415-0 / Trends Neurosci. (1999)
10.1016/S1097-2765(03)00090-X / Mol. Cell. (2003)
{'key': '2023072219080872200_BIB36', 'first-page': '123', 'volume': '15', 'year': '2001', 'journal-title': 'J. Biol. Regul. Homeost. Agents.'} / J. Biol. Regul. Homeost. Agents. (2001)
10.1074/jbc.M302460200 / J. Biol. Chem. (2003)
10.1074/jbc.M311145200 / J. Biol. Chem. (2004)
10.1093/nar/17.15.6419 / Nucleic Acids Res. (1989)
10.1021/bi0487239 / Biochemistry. (2004)
10.1091/mbc.e04-08-0740 / Mol. Biol. Cell. (2005)
10.1196/annals.1329.068 / Ann. NY Acad. Sci. (2004)
10.1074/jbc.M311761200 / J. Biol. Chem. (2004)
10.1210/mend.14.8.0497 / Mol. Endocrinol. (2000)
10.1083/jcb.153.7.1511 / J. Cell Biol. (2001)
10.1093/hmg/10.17.1807 / Hum. Mol. Genet. (2001)
10.4161/cc.4.3.1521 / Cell Cycle. (2005)
10.1093/hmg/6.3.487 / Hum. Mol. Genet. (1997)
10.1091/mbc.8.11.2291 / Mol. Biol. Cell. (1997)
10.1091/mbc.10.7.2265 / Mol. Biol. Cell. (1999)

Dates

Type	When
Created	20 years, 1 month ago (July 18, 2005, 2:38 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 3:08 p.m.)
Indexed	2 months ago (July 2, 2025, 3:08 p.m.)
Issued	20 years, 1 month ago (July 18, 2005)
Published	20 years, 1 month ago (July 18, 2005)
Published Online	20 years, 1 month ago (July 18, 2005)
Published Print	20 years, 1 month ago (July 18, 2005)

Funders 0

None

BibTeX

@article{Mills_2005, title={Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors}, volume={170}, ISSN={0021-9525}, url={http://dx.doi.org/10.1083/jcb.200503106}, DOI={10.1083/jcb.200503106}, number={2}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Mills, Ian G. and Gaughan, Luke and Robson, Craig and Ross, Theodora and McCracken, Stuart and Kelly, John and Neal, David E.}, year={2005}, month=jul, pages={191–200} }

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      "year": "1999",
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      "first-page": "17524",
      "DOI": "10.1074/jbc.M313703200",
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      "journal-title": "J. Biol. Chem."
    },
    {
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      "first-page": "33",
      "DOI": "10.1038/nm972",
      "volume": "10",
      "year": "2004",
      "journal-title": "Nat. Med."
    },
    {
      "key": "2023072219080872200_BIB7",
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      "first-page": "411",
      "DOI": "10.1093/embo-reports/kvd092",
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      "first-page": "1503",
      "DOI": "10.1083/jcb.147.7.1503",
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      "first-page": "1051",
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      "first-page": "1031",
      "DOI": "10.1242/jcs.111.8.1031",
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      "key": "2023072219080872200_BIB14",
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      "first-page": "11824",
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      "journal-title": "Proc. Natl. Acad. Sci. USA."
    },
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      "key": "2023072219080872200_BIB16",
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      "first-page": "5593",
      "DOI": "10.1091/mbc.e04-06-0468",
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      "first-page": "635",
      "DOI": "10.1083/jcb.122.3.635",
      "volume": "122",
      "year": "1993",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "2023072219080872200_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "537",
      "DOI": "10.1083/jcb.149.3.537",
      "volume": "149",
      "year": "2000",
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    {
      "key": "2023072219080872200_BIB19",
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      "first-page": "14294",
      "DOI": "10.1074/jbc.M312645200",
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      "key": "2023072219080872200_BIB21",
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      "first-page": "2855",
      "DOI": "10.1002/j.1460-2075.1993.tb05947.x",
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      "year": "1993",
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      "key": "2023072219080872200_BIB22",
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      "first-page": "19897",
      "DOI": "10.1074/jbc.M112310200",
      "volume": "277",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "2023072219080872200_BIB23",
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      "first-page": "13442",
      "DOI": "10.1074/jbc.M006598200",
      "volume": "276",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "2023072219080872200_BIB24",
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      "first-page": "5679",
      "DOI": "10.1073/pnas.94.11.5679",
      "volume": "94",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA."
    },
    {
      "key": "2023072219080872200_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "135",
      "DOI": "10.1006/bbrc.1999.1776",
      "volume": "266",
      "year": "1999",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "2023072219080872200_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "39271",
      "DOI": "10.1074/jbc.C100401200",
      "volume": "276",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "2023072219080872200_BIB27",
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      "first-page": "445",
      "DOI": "10.1016/S0092-8674(04)00117-5",
      "volume": "116",
      "year": "2004",
      "journal-title": "Cell."
    },
    {
      "key": "2023072219080872200_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "46230",
      "DOI": "10.1074/jbc.M108177200",
      "volume": "276",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "2023072219080872200_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "1721",
      "DOI": "10.1091/mbc.6.12.1721",
      "volume": "6",
      "year": "1995",
      "journal-title": "Mol. Biol. Cell."
    },
    {
      "key": "2023072219080872200_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "1618",
      "DOI": "10.1210/mend.14.10.0541",
      "volume": "14",
      "year": "2000",
      "journal-title": "Mol. Endocrinol."
    },
    {
      "key": "2023072219080872200_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "495",
      "DOI": "10.1126/science.1092586",
      "volume": "303",
      "year": "2004",
      "journal-title": "Science."
    },
    {
      "key": "2023072219080872200_BIB32",
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      "first-page": "4371",
      "DOI": "10.1038/sj.emboj.7600445",
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    {
      "key": "2023072219080872200_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "351",
      "DOI": "10.1172/JCI0215529",
      "volume": "110",
      "year": "2002",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "2023072219080872200_BIB34",
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      "first-page": "248",
      "DOI": "10.1016/S0166-2236(99)01415-0",
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      "year": "1999",
      "journal-title": "Trends Neurosci."
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      "key": "2023072219080872200_BIB35",
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      "first-page": "695",
      "DOI": "10.1016/S1097-2765(03)00090-X",
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      "key": "2023072219080872200_BIB36",
      "first-page": "123",
      "volume": "15",
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      "journal-title": "J. Biol. Regul. Homeost. Agents."
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    {
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      "first-page": "41998",
      "DOI": "10.1074/jbc.M302460200",
      "volume": "278",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "2023072219080872200_BIB38",
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      "first-page": "1922",
      "DOI": "10.1074/jbc.M311145200",
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    {
      "key": "2023072219080872200_BIB39",
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      "first-page": "6419",
      "DOI": "10.1093/nar/17.15.6419",
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      "journal-title": "Nucleic Acids Res."
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    {
      "key": "2023072219080872200_BIB40",
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      "first-page": "15418",
      "DOI": "10.1021/bi0487239",
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      "journal-title": "Biochemistry."
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    {
      "key": "2023072219080872200_BIB41",
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      "first-page": "717",
      "DOI": "10.1091/mbc.e04-08-0740",
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    {
      "key": "2023072219080872200_BIB42",
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      "first-page": "587",
      "DOI": "10.1196/annals.1329.068",
      "volume": "1030",
      "year": "2004",
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    {
      "key": "2023072219080872200_BIB43",
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      "first-page": "8389",
      "DOI": "10.1074/jbc.M311761200",
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    {
      "key": "2023072219080872200_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "1162",
      "DOI": "10.1210/mend.14.8.0497",
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