DOI: 10.1083/jcb.200411089. MCAK associates with the tips of polymerizing microtubules

MCAK associates with the tips of polymerizing microtubules

10.1083/jcb.200411089

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

MCAK is a member of the kinesin-13 family of microtubule (MT)-depolymerizing kinesins. We show that the potent MT depolymerizer MCAK tracks (treadmills) with the tips of polymerizing MTs in living cells. Tip tracking of MCAK is inhibited by phosphorylation and is dependent on the extreme COOH-terminal tail of MCAK. Tip tracking is not essential for MCAK's MT-depolymerizing activity. We propose that tip tracking is a mechanism by which MCAK is preferentially localized to regions of the cell that modulate the plus ends of MTs.

Bibliography

Moore, A. T., Rankin, K. E., von Dassow, G., Peris, L., Wagenbach, M., Ovechkina, Y., Andrieux, A., Job, D., & Wordeman, L. (2005). MCAK associates with the tips of polymerizing microtubules. The Journal of Cell Biology, 169(3), 391â397.

Authors 9

Ayana T. Moore (first)
Kathleen E. Rankin (additional)
George von Dassow (additional)
Leticia Peris (additional)
Michael Wagenbach (additional)
Yulia Ovechkina (additional)
Annie Andrieux (additional)
Didier Job (additional)
Linda Wordeman (additional)

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Dates

Type	When
Created	20 years, 3 months ago (May 9, 2005, 3:42 p.m.)
Deposited	2 years, 1 month ago (July 28, 2023, 5:05 p.m.)
Indexed	2 months, 3 weeks ago (June 11, 2025, 10:06 a.m.)
Issued	20 years, 3 months ago (May 9, 2005)
Published	20 years, 3 months ago (May 9, 2005)
Published Online	20 years, 3 months ago (May 9, 2005)
Published Print	20 years, 3 months ago (May 9, 2005)

Funders 0

None

BibTeX

@article{Moore_2005, title={MCAK associates with the tips of polymerizing microtubules}, volume={169}, ISSN={0021-9525}, url={http://dx.doi.org/10.1083/jcb.200411089}, DOI={10.1083/jcb.200411089}, number={3}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Moore, Ayana T. and Rankin, Kathleen E. and von Dassow, George and Peris, Leticia and Wagenbach, Michael and Ovechkina, Yulia and Andrieux, Annie and Job, Didier and Wordeman, Linda}, year={2005}, month=may, pages={391–397} }

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