DOI: 10.1083/jcb.200405167. Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathway

Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathway

10.1083/jcb.200405167

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

When early prophase PtK1 or Indian muntjac cells are exposed to topoisomerase II (topo II) inhibitors that induce little if any DNA damage, they are delayed from entering mitosis. We show that this delay is overridden by inhibiting the p38, but not the ATM, kinase. Treating early prophase cells with hyperosmotic medium or a histone deacetylase inhibitor similarly delays entry into mitosis, and this delay can also be prevented by inhibiting p38. Together, these results reveal that agents or stresses that induce global changes in chromatin topology during G2 delay entry into mitosis, independent of the ATM-mediated DNA damage checkpoint, by activating the p38 MAPK checkpoint. The presence of this pathway obviates the necessity of postulating the existence of multiple “chromatin modification” checkpoints during G2. Lastly, cells that enter mitosis in the presence of topo II inhibitors form metaphase spindles that are delayed in entering anaphase via the spindle assembly, and not the p38, checkpoint.

Bibliography

Mikhailov, A., Shinohara, M., & Rieder, C. L. (2004). Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathway. The Journal of Cell Biology, 166(4), 517â526.

Authors 3

Alexei Mikhailov (first)
Mio Shinohara (additional)
Conly L. Rieder (additional)

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Dates

Type	When
Created	21 years ago (Aug. 9, 2004, 8:13 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 2:20 p.m.)
Indexed	10 months, 2 weeks ago (Oct. 5, 2024, 8:31 p.m.)
Issued	21 years ago (Aug. 9, 2004)
Published	21 years ago (Aug. 9, 2004)
Published Online	21 years ago (Aug. 9, 2004)
Published Print	21 years ago (Aug. 16, 2004)

Funders 0

None

BibTeX

@article{Mikhailov_2004, title={Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathway}, volume={166}, ISSN={0021-9525}, url={http://dx.doi.org/10.1083/jcb.200405167}, DOI={10.1083/jcb.200405167}, number={4}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Mikhailov, Alexei and Shinohara, Mio and Rieder, Conly L.}, year={2004}, month=aug, pages={517–526} }

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  "abstract": "<jats:p>When early prophase PtK1 or Indian muntjac cells are exposed to topoisomerase II (topo II) inhibitors that induce little if any DNA damage, they are delayed from entering mitosis. We show that this delay is overridden by inhibiting the p38, but not the ATM, kinase. Treating early prophase cells with hyperosmotic medium or a histone deacetylase inhibitor similarly delays entry into mitosis, and this delay can also be prevented by inhibiting p38. Together, these results reveal that agents or stresses that induce global changes in chromatin topology during G2 delay entry into mitosis, independent of the ATM-mediated DNA damage checkpoint, by activating the p38 MAPK checkpoint. The presence of this pathway obviates the necessity of postulating the existence of multiple \u201cchromatin modification\u201d checkpoints during G2. Lastly, cells that enter mitosis in the presence of topo II inhibitors form metaphase spindles that are delayed in entering anaphase via the spindle assembly, and not the p38, checkpoint.</jats:p>",
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