DOI: 10.1083/jcb.200306067. α3β1 integrin–CD151, a component of the cadherin–catenin complex, regulates PTPμ expression and cell

α3β1 integrin–CD151, a component of the cadherin–catenin complex, regulates PTPμ expression and cell–cell adhesion

10.1083/jcb.200306067

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

The β1 family of integrins has been primarily studied as a set of receptors for the extracellular matrix. In this paper, we define a novel role for α3β1 integrin in association with the tetraspanin CD151 as a component of a cell–cell adhesion complex in epithelial cells that directly stimulates cadherin-mediated adhesion. The integrin–tetraspanin complex affects epithelial cell–cell adhesion at the level of gene expression both by regulating expression of PTPμ and by organizing a multimolecular complex containing PKCβII, RACK1, PTPμ, β-catenin, and E-cadherin. These findings demonstrate how integrin-based signaling can regulate complex biological responses at multiple levels to determine cell morphology and behavior.

Bibliography

Chattopadhyay, N., Wang, Z., Ashman, L. K., Brady-Kalnay, S. M., & Kreidberg, J. A. (2003). Î±3Î²1 integrinâCD151, a component of the cadherinâcatenin complex, regulates PTPÎ¼ expression and cellâcell adhesion. The Journal of Cell Biology, 163(6), 1351â1362.

Authors 5

Nibedita Chattopadhyay (first)
Zemin Wang (additional)
Leonie K. Ashman (additional)
Susann M. Brady-Kalnay (additional)
Jordan A. Kreidberg (additional)

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Dates

Type	When
Created	21 years, 8 months ago (Dec. 22, 2003, 7:07 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 10:52 a.m.)
Indexed	4 months, 3 weeks ago (April 6, 2025, 5:22 p.m.)
Issued	21 years, 8 months ago (Dec. 22, 2003)
Published	21 years, 8 months ago (Dec. 22, 2003)
Published Online	21 years, 8 months ago (Dec. 22, 2003)
Published Print	21 years, 8 months ago (Dec. 22, 2003)

Funders 0

None

BibTeX

@article{Chattopadhyay_2003, title={α3β1 integrin–CD151, a component of the cadherin–catenin complex, regulates PTPμ expression and cell–cell adhesion}, volume={163}, ISSN={0021-9525}, url={http://dx.doi.org/10.1083/jcb.200306067}, DOI={10.1083/jcb.200306067}, number={6}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Chattopadhyay, Nibedita and Wang, Zemin and Ashman, Leonie K. and Brady-Kalnay, Susann M. and Kreidberg, Jordan A.}, year={2003}, month=dec, pages={1351–1362} }

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