DOI: 10.1083/jcb.200305018. Juxtaparanodal clustering of <i>Shaker</i>-like K+ channels in myelinated axons depends on Caspr2 and TAG-1

Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1

10.1083/jcb.200305018

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

In myelinated axons, K+ channels are concealed under the myelin sheath in the juxtaparanodal region, where they are associated with Caspr2, a member of the neurexin superfamily. Deletion of Caspr2 in mice by gene targeting revealed that it is required to maintain K+ channels at this location. Furthermore, we show that the localization of Caspr2 and clustering of K+ channels at the juxtaparanodal region depends on the presence of TAG-1, an immunoglobulin-like cell adhesion molecule that binds Caspr2. These results demonstrate that Caspr2 and TAG-1 form a scaffold that is necessary to maintain K+ channels at the juxtaparanodal region, suggesting that axon–glia interactions mediated by these proteins allow myelinating glial cells to organize ion channels in the underlying axonal membrane.

Bibliography

Poliak, S., Salomon, D., Elhanany, H., Sabanay, H., Kiernan, B., Pevny, L., Stewart, C. L., Xu, X., Chiu, S.-Y., Shrager, P., Furley, A. J. W., & Peles, E. (2003). Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. The Journal of Cell Biology, 162(6), 1149â1160.

Authors 12

Sebastian Poliak (first)
Daniela Salomon (additional)
Hadas Elhanany (additional)
Helena Sabanay (additional)
Brent Kiernan (additional)
Larysa Pevny (additional)
Colin L. Stewart (additional)
Xiaorong Xu (additional)
Shing-Yan Chiu (additional)
Peter Shrager (additional)
Andrew J.W. Furley (additional)
Elior Peles (additional)

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Dates

Type	When
Created	21 years, 11 months ago (Sept. 8, 2003, 10:40 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 1:32 p.m.)
Indexed	3 days, 20 hours ago (Sept. 2, 2025, 6:36 a.m.)
Issued	21 years, 11 months ago (Sept. 8, 2003)
Published	21 years, 11 months ago (Sept. 8, 2003)
Published Online	21 years, 11 months ago (Sept. 8, 2003)
Published Print	21 years, 11 months ago (Sept. 15, 2003)

Funders 0

None

BibTeX

@article{Poliak_2003, title={Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1}, volume={162}, ISSN={0021-9525}, url={http://dx.doi.org/10.1083/jcb.200305018}, DOI={10.1083/jcb.200305018}, number={6}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Poliak, Sebastian and Salomon, Daniela and Elhanany, Hadas and Sabanay, Helena and Kiernan, Brent and Pevny, Larysa and Stewart, Colin L. and Xu, Xiaorong and Chiu, Shing-Yan and Shrager, Peter and Furley, Andrew J.W. and Peles, Elior}, year={2003}, month=sep, pages={1149–1160} }

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