DOI: 10.1083/jcb.200304135. Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation

Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation

10.1083/jcb.200304135

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

High mobility group box 1 (HMGB1) is an abundant chromatin protein that acts as a cytokine when released in the extracellular milieu by necrotic and inflammatory cells. Here, we show that extracellular HMGB1 and its receptor for advanced glycation end products (RAGE) induce both migration and proliferation of vessel-associated stem cells (mesoangioblasts), and thus may play a role in muscle tissue regeneration. In vitro, HMGB1 induces migration and proliferation of both adult and embryonic mesoangioblasts, and disrupts the barrier function of endothelial monolayers. In living mice, mesoangioblasts injected into the femoral artery migrate close to HMGB1-loaded heparin-Sepharose beads implanted in healthy muscle, but are unresponsive to control beads. Interestingly, α-sarcoglycan null dystrophic muscle contains elevated levels of HMGB1; however, mesoangioblasts migrate into dystrophic muscle even if their RAGE receptor is disabled. This implies that the HMGB1–RAGE interaction is sufficient, but not necessary, for mesoangioblast homing; a different pathway might coexist. Although the role of endogenous HMGB1 in the reconstruction of dystrophic muscle remains to be clarified, injected HMGB1 may be used to promote tissue regeneration.

Bibliography

Palumbo, R., Sampaolesi, M., De Marchis, F., Tonlorenzi, R., Colombetti, S., Mondino, A., Cossu, G., & Bianchi, M. E. (2004). Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation. The Journal of Cell Biology, 164(3), 441â449.

Authors 8

Roberta Palumbo (first)
Maurilio Sampaolesi (additional)
Francesco De Marchis (additional)
Rossana Tonlorenzi (additional)
Sara Colombetti (additional)
Anna Mondino (additional)
Giulio Cossu (additional)
Marco E. Bianchi (additional)

References 34 Referenced 362

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Dates

Type	When
Created	21 years, 6 months ago (Jan. 26, 2004, 8:33 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 10:49 a.m.)
Indexed	5 days, 18 hours ago (Aug. 19, 2025, 6:17 a.m.)
Issued	21 years, 6 months ago (Jan. 26, 2004)
Published	21 years, 6 months ago (Jan. 26, 2004)
Published Online	21 years, 6 months ago (Jan. 26, 2004)
Published Print	21 years, 6 months ago (Feb. 2, 2004)

Funders 0

None

BibTeX

@article{Palumbo_2004, title={Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation}, volume={164}, ISSN={0021-9525}, url={http://dx.doi.org/10.1083/jcb.200304135}, DOI={10.1083/jcb.200304135}, number={3}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Palumbo, Roberta and Sampaolesi, Maurilio and De Marchis, Francesco and Tonlorenzi, Rossana and Colombetti, Sara and Mondino, Anna and Cossu, Giulio and Bianchi, Marco E.}, year={2004}, month=jan, pages={441–449} }

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