DOI: 10.1083/jcb.200212114. Differential regulation of cell motility and invasion by FAK

Differential regulation of cell motility and invasion by FAK

10.1083/jcb.200212114

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

Cell migration and invasion are fundamental components of tumor cell metastasis. Increased focal adhesion kinase (FAK) expression and tyrosine phosphorylation are connected with elevated tumorigenesis. Null mutation of FAK results in embryonic lethality, and FAK−/− fibroblasts exhibit cell migration defects in culture. Here we show that viral Src (v-Src) transformation of FAK−/− cells promotes integrin-stimulated motility equal to stable FAK reexpression. However, FAK−/− v-Src cells were not invasive, and FAK reexpression, Tyr-397 phosphorylation, and FAK kinase activity were required for the generation of an invasive cell phenotype. Cell invasion was linked to transient FAK accumulation at lamellipodia, formation of a FAK–Src-p130Cas–Dock180 signaling complex, elevated Rac and c-Jun NH2-terminal kinase activation, and increased matrix metalloproteinase expression and activity. Our studies support a dual role for FAK in promoting cell motility and invasion through the activation of distinct signaling pathways.

Bibliography

Hsia, D. A., Mitra, S. K., Hauck, C. R., Streblow, D. N., Nelson, J. A., Ilic, D., Huang, S., Li, E., Nemerow, G. R., Leng, J., Spencer, K. S. R., Cheresh, D. A., & Schlaepfer, D. D. (2003). Differential regulation of cell motility and invasion by FAK. The Journal of Cell Biology, 160(5), 753â767.

Authors 13

Datsun A. Hsia (first)
Satyajit K. Mitra (additional)
Christof R. Hauck (additional)
Daniel N. Streblow (additional)
Jay A. Nelson (additional)
Dusko Ilic (additional)
Shuang Huang (additional)
Erguang Li (additional)
Glen R. Nemerow (additional)
Jay Leng (additional)
Kathryn S.R. Spencer (additional)
David A. Cheresh (additional)
David D. Schlaepfer (additional)

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Dates

Type	When
Created	22 years, 5 months ago (March 3, 2003, 4:05 p.m.)
Deposited	2 years, 1 month ago (July 21, 2023, 10:03 p.m.)
Indexed	2 months, 1 week ago (June 18, 2025, 8:43 a.m.)
Issued	22 years, 5 months ago (March 3, 2003)
Published	22 years, 5 months ago (March 3, 2003)
Published Online	22 years, 5 months ago (March 3, 2003)
Published Print	22 years, 5 months ago (March 3, 2003)

Funders 0

None

BibTeX

@article{Hsia_2003, title={Differential regulation of cell motility and invasion by FAK}, volume={160}, ISSN={0021-9525}, url={http://dx.doi.org/10.1083/jcb.200212114}, DOI={10.1083/jcb.200212114}, number={5}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Hsia, Datsun A. and Mitra, Satyajit K. and Hauck, Christof R. and Streblow, Daniel N. and Nelson, Jay A. and Ilic, Dusko and Huang, Shuang and Li, Erguang and Nemerow, Glen R. and Leng, Jay and Spencer, Kathryn S.R. and Cheresh, David A. and Schlaepfer, David D.}, year={2003}, month=mar, pages={753–767} }

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