DOI: 10.1083/jcb.200211113. The inner membrane protein Mdm33 controls mitochondrial morphology in yeast

The inner membrane protein Mdm33 controls mitochondrial morphology in yeast

10.1083/jcb.200211113

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

Mitochondrial distribution and morphology depend on MDM33, a Saccharomyces cerevisiae gene encoding a novel protein of the mitochondrial inner membrane. Cells lacking Mdm33 contain ring-shaped, mostly interconnected mitochondria, which are able to form large hollow spheres. On the ultrastructural level, these aberrant organelles display extremely elongated stretches of outer and inner membranes enclosing a very narrow matrix space. Dilated parts of Δmdm33 mitochondria contain well-developed cristae. Overexpression of Mdm33 leads to growth arrest, aggregation of mitochondria, and generation of aberrant inner membrane structures, including septa, inner membrane fragments, and loss of inner membrane cristae. The MDM33 gene is required for the formation of net-like mitochondria in mutants lacking components of the outer membrane fission machinery, and mitochondrial fusion is required for the formation of extended ring-like mitochondria in cells lacking the MDM33 gene. The Mdm33 protein assembles into an oligomeric complex in the inner membrane where it performs homotypic protein–protein interactions. Our results indicate that Mdm33 plays a distinct role in the mitochondrial inner membrane to control mitochondrial morphology. We propose that Mdm33 is involved in fission of the mitochondrial inner membrane.

Bibliography

Messerschmitt, M., Jakobs, S., Vogel, F., Fritz, S., Dimmer, K. S., Neupert, W., & Westermann, B. (2003). The inner membrane protein Mdm33 controls mitochondrial morphology in yeast. The Journal of Cell Biology, 160(4), 553â564.

Authors 7

Marlies Messerschmitt (first)
Stefan Jakobs (additional)
Frank Vogel (additional)
Stefan Fritz (additional)
Kai Stefan Dimmer (additional)
Walter Neupert (additional)
Benedikt Westermann (additional)

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Dates

Type	When
Created	22 years, 6 months ago (Feb. 18, 2003, 2:45 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 10:08 a.m.)
Indexed	1 month ago (July 25, 2025, 6:19 a.m.)
Issued	22 years, 6 months ago (Feb. 17, 2003)
Published	22 years, 6 months ago (Feb. 17, 2003)
Published Online	22 years, 6 months ago (Feb. 18, 2003)
Published Print	22 years, 6 months ago (Feb. 17, 2003)

Funders 0

None

BibTeX

@article{Messerschmitt_2003, title={The inner membrane protein Mdm33 controls mitochondrial morphology in yeast}, volume={160}, ISSN={0021-9525}, url={http://dx.doi.org/10.1083/jcb.200211113}, DOI={10.1083/jcb.200211113}, number={4}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Messerschmitt, Marlies and Jakobs, Stefan and Vogel, Frank and Fritz, Stefan and Dimmer, Kai Stefan and Neupert, Walter and Westermann, Benedikt}, year={2003}, month=feb, pages={553–564} }

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