DOI: 10.1083/jcb.200108150. Identification of a novel population of muscle stem cells in mice

Identification of a novel population of muscle stem cells in mice

10.1083/jcb.200108150

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

Three populations of myogenic cells were isolated from normal mouse skeletal muscle based on their adhesion characteristics and proliferation behaviors. Although two of these populations displayed satellite cell characteristics, a third population of long-time proliferating cells expressing hematopoietic stem cell markers was also identified. This third population comprises cells that retain their phenotype for more than 30 passages with normal karyotype and can differentiate into muscle, neural, and endothelial lineages both in vitro and in vivo. In contrast to the other two populations of myogenic cells, the transplantation of the long-time proliferating cells improved the efficiency of muscle regeneration and dystrophin delivery to dystrophic muscle. The long-time proliferating cells' ability to proliferate in vivo for an extended period of time, combined with their strong capacity for self-renewal, their multipotent differentiation, and their immune-privileged behavior, reveals, at least in part, the basis for the improvement of cell transplantation. Our results suggest that this novel population of muscle-derived stem cells will significantly improve muscle cell–mediated therapies.

Bibliography

Qu-Petersen, Z., Deasy, B., Jankowski, R., Ikezawa, M., Cummins, J., Pruchnic, R., Mytinger, J., Cao, B., Gates, C., Wernig, A., & Huard, J. (2002). Identification of a novel population of muscle stem cells in mice. The Journal of Cell Biology, 157(5), 851â864.

Authors 11

Zhuqing Qu-Petersen (first)
Bridget Deasy (additional)
Ron Jankowski (additional)
Makato Ikezawa (additional)
James Cummins (additional)
Ryan Pruchnic (additional)
John Mytinger (additional)
Baohong Cao (additional)
Charley Gates (additional)
Anton Wernig (additional)
Johnny Huard (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:48 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 9:30 a.m.)
Indexed	8 hours, 56 minutes ago (Sept. 4, 2025, 10:24 a.m.)
Issued	23 years, 3 months ago (May 20, 2002)
Published	23 years, 3 months ago (May 20, 2002)
Published Online	23 years, 3 months ago (May 20, 2002)
Published Print	23 years, 3 months ago (May 28, 2002)

Funders 0

None

BibTeX

@article{Qu_Petersen_2002, title={Identification of a novel population of muscle stem cells in mice}, volume={157}, ISSN={0021-9525}, url={http://dx.doi.org/10.1083/jcb.200108150}, DOI={10.1083/jcb.200108150}, number={5}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Qu-Petersen, Zhuqing and Deasy, Bridget and Jankowski, Ron and Ikezawa, Makato and Cummins, James and Pruchnic, Ryan and Mytinger, John and Cao, Baohong and Gates, Charley and Wernig, Anton and Huard, Johnny}, year={2002}, month=may, pages={851–864} }

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