DOI: 10.1083/jcb.152.5.935. Rer1p, a Retrieval Receptor for Endoplasmic Reticulum Membrane Proteins, Is Dynamically Localized to the Golgi Apparatus by Coatomer

Rer1p, a Retrieval Receptor for Endoplasmic Reticulum Membrane Proteins, Is Dynamically Localized to the Golgi Apparatus by Coatomer

10.1083/jcb.152.5.935

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

Rer1p, a yeast Golgi membrane protein, is required for the retrieval of a set of endoplasmic reticulum (ER) membrane proteins. We present the first evidence that Rer1p directly interacts with the transmembrane domain (TMD) of Sec12p which contains a retrieval signal. A green fluorescent protein (GFP) fusion of Rer1p rapidly cycles between the Golgi and the ER. Either a lesion of coatomer or deletion of the COOH-terminal tail of Rer1p causes its mislocalization to the vacuole. The COOH-terminal Rer1p tail interacts in vitro with a coatomer complex containing α and γ subunits. These findings not only give the proof that Rer1p is a novel type of retrieval receptor recognizing the TMD in the Golgi but also indicate that coatomer actively regulates the function and localization of Rer1p.

Bibliography

Sato, K., Sato, M., & Nakano, A. (2001). Rer1p, a Retrieval Receptor for Endoplasmic Reticulum Membrane Proteins, Is Dynamically Localized to the Golgi Apparatus by Coatomer. The Journal of Cell Biology, 152(5), 935â944.

Authors 3

Ken Sato (first)
Miyuki Sato (additional)
Akihiko Nakano (additional)

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{'key': '2023072211384195100_N0x3019e00N0x2b546c0', 'first-page': '31', 'article-title': 'Human Rer1 is localized to the Golgi apparatus and complements the deletion of the homologous Rer1 protein of Saccharomyces cerevisiae', 'volume': '74', 'author': 'Füllekrug', 'year': '1997', 'journal-title': 'Eur. J. Cell Biol.'} / Eur. J. Cell Biol. / Human Rer1 is localized to the Golgi apparatus and complements the deletion of the homologous Rer1 protein of Saccharomyces cerevisiae by Füllekrug (1997)
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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:46 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 7:39 a.m.)
Indexed	11 months, 4 weeks ago (Sept. 8, 2024, 7:41 a.m.)
Issued	24 years, 6 months ago (March 5, 2001)
Published	24 years, 6 months ago (March 5, 2001)
Published Online	24 years, 6 months ago (March 5, 2001)
Published Print	24 years, 6 months ago (March 5, 2001)

Funders 0

None

BibTeX

@article{Sato_2001, title={Rer1p, a Retrieval Receptor for Endoplasmic Reticulum Membrane Proteins, Is Dynamically Localized to the Golgi Apparatus by Coatomer}, volume={152}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.152.5.935}, DOI={10.1083/jcb.152.5.935}, number={5}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Sato, Ken and Sato, Miyuki and Nakano, Akihiko}, year={2001}, month=mar, pages={935–944} }

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