DOI: 10.1083/jcb.151.3.673. The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II

The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II–Positive Lysosomal Compartments

10.1083/jcb.151.3.673

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

Many receptors for endocytosis recycle into and out of cells through early endosomes. We now find in dendritic cells that the DEC-205 multilectin receptor targets late endosomes or lysosomes rich in major histocompatibility complex class II (MHC II) products, whereas the homologous macrophage mannose receptor (MMR), as expected, is found in more peripheral endosomes. To analyze this finding, the cytosolic tails of DEC-205 and MMR were fused to the external domain of the CD16 Fcγ receptor and studied in stable L cell transfectants. The two cytosolic domains each mediated rapid uptake of human immunoglobulin (Ig)G followed by recycling of intact CD16 to the cell surface. However, the DEC-205 tail recycled the CD16 through MHC II–positive late endosomal/lysosomal vacuoles and also mediated a 100-fold increase in antigen presentation. The mechanism of late endosomal targeting, which occurred in the absence of human IgG, involved two functional regions: a membrane-proximal region with a coated pit sequence for uptake, and a distal region with an EDE triad for the unusual deeper targeting. Therefore, the DEC-205 cytosolic domain mediates a new pathway of receptor-mediated endocytosis that entails efficient recycling through late endosomes and a greatly enhanced efficiency of antigen presentation to CD4+ T cells.

Bibliography

Mahnke, K., Guo, M., Lee, S., Sepulveda, H., Swain, S. L., Nussenzweig, M., & Steinman, R. M. (2000). The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class IIâPositive Lysosomal Compartments. The Journal of Cell Biology, 151(3), 673â684.

Authors 7

Karsten Mahnke (first)
Ming Guo (additional)
Sena Lee (additional)
Homero Sepulveda (additional)
Suzy L. Swain (additional)
Michel Nussenzweig (additional)
Ralph M. Steinman (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:45 p.m.)
Deposited	2 years, 1 month ago (July 28, 2023, 10:33 p.m.)
Indexed	1 week, 1 day ago (Aug. 23, 2025, 12:59 a.m.)
Issued	24 years, 10 months ago (Oct. 30, 2000)
Published	24 years, 10 months ago (Oct. 30, 2000)
Published Online	24 years, 10 months ago (Oct. 30, 2000)
Published Print	24 years, 10 months ago (Oct. 30, 2000)

Funders 0

None

BibTeX

@article{Mahnke_2000, title={The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II–Positive Lysosomal Compartments}, volume={151}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.151.3.673}, DOI={10.1083/jcb.151.3.673}, number={3}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Mahnke, Karsten and Guo, Ming and Lee, Sena and Sepulveda, Homero and Swain, Suzy L. and Nussenzweig, Michel and Steinman, Ralph M.}, year={2000}, month=oct, pages={673–684} }

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