DOI: 10.1083/jcb.147.5.913. Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy

Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy

10.1083/jcb.147.5.913

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

The nuclear lamina is a protein meshwork lining the nucleoplasmic face of the inner nuclear membrane and represents an important determinant of interphase nuclear architecture. Its major components are the A- and B-type lamins. Whereas B-type lamins are found in all mammalian cells, A-type lamin expression is developmentally regulated. In the mouse, A-type lamins do not appear until midway through embryonic development, suggesting that these proteins may be involved in the regulation of terminal differentiation. Here we show that mice lacking A-type lamins develop to term with no overt abnormalities. However, their postnatal growth is severely retarded and is characterized by the appearance of muscular dystrophy. This phenotype is associated with ultrastructural perturbations to the nuclear envelope. These include the mislocalization of emerin, an inner nuclear membrane protein, defects in which are implicated in Emery-Dreifuss muscular dystrophy (EDMD), one of the three major X-linked dystrophies. Mice lacking the A-type lamins exhibit tissue-specific alterations to their nuclear envelope integrity and emerin distribution. In skeletal and cardiac muscles, this is manifest as a dystrophic condition related to EDMD.

Bibliography

Sullivan, T., Escalante-Alcalde, D., Bhatt, H., Anver, M., Bhat, N., Nagashima, K., Stewart, C. L., & Burke, B. (1999). Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy. The Journal of Cell Biology, 147(5), 913â920.

Authors 8

Teresa Sullivan (first)
Diana Escalante-Alcalde (additional)
Harshida Bhatt (additional)
Miriam Anver (additional)
Narayan Bhat (additional)
Kunio Nagashima (additional)
Colin L. Stewart (additional)
Brian Burke (additional)

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Dates

Type	When
Created	23 years ago (July 26, 2002, 12:45 p.m.)
Deposited	2 years ago (July 28, 2023, 9:25 p.m.)
Indexed	1 day, 22 hours ago (Aug. 21, 2025, 1:39 p.m.)
Issued	25 years, 8 months ago (Nov. 29, 1999)
Published	25 years, 8 months ago (Nov. 29, 1999)
Published Online	25 years, 8 months ago (Nov. 29, 1999)
Published Print	25 years, 8 months ago (Nov. 29, 1999)

Funders 0

None

BibTeX

@article{Sullivan_1999, title={Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy}, volume={147}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.147.5.913}, DOI={10.1083/jcb.147.5.913}, number={5}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Sullivan, Teresa and Escalante-Alcalde, Diana and Bhatt, Harshida and Anver, Miriam and Bhat, Narayan and Nagashima, Kunio and Stewart, Colin L. and Burke, Brian}, year={1999}, month=nov, pages={913–920} }

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