DOI: 10.1083/jcb.145.7.1461. Integrin-mediated Activation of Focal Adhesion Kinase Is Required for Signaling to Jun NH2-terminal Kinase and Progression through the G1 Phase of the Cell Cycle

Integrin-mediated Activation of Focal Adhesion Kinase Is Required for Signaling to Jun NH2-terminal Kinase and Progression through the G1 Phase of the Cell Cycle

10.1083/jcb.145.7.1461

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

The extracellular matrix exerts a stringent control on the proliferation of normal cells, suggesting the existence of a mitogenic signaling pathway activated by integrins, but not significantly by growth factor receptors. Herein, we provide evidence that integrins cause a significant and protracted activation of Jun NH2-terminal kinase (JNK), while several growth factors cause more modest or no activation of this enzyme. Integrin-mediated stimulation of JNK required the association of focal adhesion kinase (FAK) with a Src kinase and p130CAS, the phosphorylation of p130CAS, and subsequently, the recruitment of Crk. Ras and PI-3K were not required. FAK–JNK signaling was necessary for proper progression through the G1 phase of the cell cycle. These findings establish a role for FAK in both the activation of JNK and the control of the cell cycle, and identify a physiological stimulus for JNK signaling that is consistent with the role of Jun in both proliferation and transformation.

Bibliography

Oktay, M., Wary, K. K., Dans, M., Birge, R. B., & Giancotti, F. G. (1999). Integrin-mediated Activation of Focal Adhesion Kinase Is Required for Signaling to Jun NH2-terminal Kinase and Progression through the G1 Phase of the Cell Cycle. The Journal of Cell Biology, 145(7), 1461â1470.

Authors 5

Maja Oktay (first)
Kishore K. Wary (additional)
Michael Dans (additional)
Raymond B. Birge (additional)
Filippo G. Giancotti (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:45 p.m.)
Deposited	2 years, 1 month ago (July 28, 2023, 8:25 p.m.)
Indexed	1 month, 1 week ago (July 20, 2025, 6:44 p.m.)
Issued	26 years, 2 months ago (June 28, 1999)
Published	26 years, 2 months ago (June 28, 1999)
Published Online	26 years, 2 months ago (June 28, 1999)
Published Print	26 years, 2 months ago (June 28, 1999)

Funders 0

None

BibTeX

@article{Oktay_1999, title={Integrin-mediated Activation of Focal Adhesion Kinase Is Required for Signaling to Jun NH2-terminal Kinase and Progression through the G1 Phase of the Cell Cycle}, volume={145}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.145.7.1461}, DOI={10.1083/jcb.145.7.1461}, number={7}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Oktay, Maja and Wary, Kishore K. and Dans, Michael and Birge, Raymond B. and Giancotti, Filippo G.}, year={1999}, month=jun, pages={1461–1470} }

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