DOI: 10.1083/jcb.145.3.539. Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain

Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein

10.1083/jcb.145.3.539

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

We have isolated a novel actin filament–binding protein, named afadin, localized at cadherin-based cell–cell adherens junctions (AJs) in various tissues and cell lines. Afadin has one PDZ domain, three proline-rich regions, and one actin filament–binding domain. We found here that afadin directly interacted with a family of the immunoglobulin superfamily, which was isolated originally as the poliovirus receptor–related protein (PRR) family consisting of PRR1 and -2, and has been identified recently to be the alphaherpes virus receptor. PRR has a COOH-terminal consensus motif to which the PDZ domain of afadin binds. PRR and afadin were colocalized at cadherin-based cell–cell AJs in various tissues and cell lines. In E-cadherin–expressing EL cells, PRR was recruited to cadherin-based cell–cell AJs through interaction with afadin. PRR showed Ca2+-independent cell–cell adhesion activity. These results indicate that PRR is a cell–cell adhesion molecule of the immunoglobulin superfamily which is recruited to cadherin-based cell–cell AJs through interaction with afadin. We rename PRR as nectin (taken from the Latin word “necto” meaning “to connect”).

Bibliography

Takahashi, K., Nakanishi, H., Miyahara, M., Mandai, K., Satoh, K., Satoh, A., Nishioka, H., Aoki, J., Nomoto, A., Mizoguchi, A., & Takai, Y. (1999). Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domainâcontaining Protein. The Journal of Cell Biology, 145(3), 539â549.

Authors 11

Kenichi Takahashi (first)
Hiroyuki Nakanishi (additional)
Masako Miyahara (additional)
Kenji Mandai (additional)
Keiko Satoh (additional)
Ayako Satoh (additional)
Hideo Nishioka (additional)
Junken Aoki (additional)
Akio Nomoto (additional)
Akira Mizoguchi (additional)
Yoshimi Takai (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:45 p.m.)
Deposited	2 years, 1 month ago (July 28, 2023, 8:44 p.m.)
Indexed	6 days, 9 hours ago (Aug. 26, 2025, 3:02 a.m.)
Issued	26 years, 3 months ago (May 3, 1999)
Published	26 years, 3 months ago (May 3, 1999)
Published Online	26 years, 3 months ago (May 3, 1999)
Published Print	26 years, 3 months ago (May 3, 1999)

Funders 0

None

BibTeX

@article{Takahashi_1999, title={Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein}, volume={145}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.145.3.539}, DOI={10.1083/jcb.145.3.539}, number={3}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Takahashi, Kenichi and Nakanishi, Hiroyuki and Miyahara, Masako and Mandai, Kenji and Satoh, Keiko and Satoh, Ayako and Nishioka, Hideo and Aoki, Junken and Nomoto, Akio and Mizoguchi, Akira and Takai, Yoshimi}, year={1999}, month=may, pages={539–549} }

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