DOI: 10.1083/jcb.143.3.601. KDEL Receptor (Erd2p)-mediated Retrograde Transport of the Cholera Toxin A Subunit from the Golgi Involves COPI, p23, and the COOH Terminus of Erd2p

KDEL Receptor (Erd2p)-mediated Retrograde Transport of the Cholera Toxin A Subunit from the Golgi Involves COPI, p23, and the COOH Terminus of Erd2p

10.1083/jcb.143.3.601

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

A cholera toxin mutant (CTX–K63) unable to raise cAMP levels was used to study in Vero cells the retrograde transport of the toxin A subunit (CTX-A–K63), which possesses a COOH-terminal KDEL retrieval signal. Microinjected GTP-γ-S inhibits the internalization as well as Golgi–ER transport of CTX-A–K63. The appearance of CTX-A–K63 in the Golgi induces a marked dispersion of Erd2p and p53 but not of the Golgi marker giantin. Erd2p is translocated under these conditions most likely to the intermediate compartment as indicated by an increased colocalization of Erd2p with mSEC13, a member of the mammalian coat protein II complex. IgGs as well as Fab fragments directed against Erd2p, β-COP, or p23, a new member of the p24 protein family, inhibit or block retrograde transport of CTX-A–K63 from the Golgi without affecting its internalization or its transport to the Golgi. Anti-Erd2p antibodies do not affect the binding of CTX-A to Erd2p, but inhibit the CTX-K63–induced translocation of Erd2p and p53.

Bibliography

Majoul, I., Sohn, K., Wieland, F. T., Pepperkok, R., Pizza, M., Hillemann, J., & SÃ¶ling, H.-D. (1998). KDEL Receptor (Erd2p)-mediated Retrograde Transport of the Cholera Toxin A Subunit from the Golgi Involves COPI, p23, and the COOH Terminus of Erd2p. The Journal of Cell Biology, 143(3), 601â612.

Authors 7

Irina Majoul (first)
Kai Sohn (additional)
Felix Theodor Wieland (additional)
Rainer Pepperkok (additional)
Mariagrazia Pizza (additional)
Jörg Hillemann (additional)
Hans-Dieter Söling (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:47 p.m.)
Deposited	2 years, 1 month ago (July 28, 2023, 9:05 p.m.)
Indexed	9 months, 1 week ago (Nov. 19, 2024, 10:42 a.m.)
Issued	26 years, 9 months ago (Nov. 2, 1998)
Published	26 years, 9 months ago (Nov. 2, 1998)
Published Online	26 years, 9 months ago (Nov. 2, 1998)
Published Print	26 years, 9 months ago (Nov. 2, 1998)

Funders 0

None

BibTeX

@article{Majoul_1998, title={KDEL Receptor (Erd2p)-mediated Retrograde Transport of the Cholera Toxin A Subunit from the Golgi Involves COPI, p23, and the COOH Terminus of Erd2p}, volume={143}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.143.3.601}, DOI={10.1083/jcb.143.3.601}, number={3}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Majoul, Irina and Sohn, Kai and Wieland, Felix Theodor and Pepperkok, Rainer and Pizza, Mariagrazia and Hillemann, Jörg and Söling, Hans-Dieter}, year={1998}, month=nov, pages={601–612} }

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    "1540-8140"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1998,
        11,
        2
      ]
    ]
  }
}