DOI: 10.1083/jcb.142.3.613. The Sorting of Mitochondrial DNA and Mitochondrial Proteins in Zygotes: Preferential Transmission of Mitochondrial DNA to the Medial Bud

The Sorting of Mitochondrial DNA and Mitochondrial Proteins in Zygotes: Preferential Transmission of Mitochondrial DNA to the Medial Bud

10.1083/jcb.142.3.613

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

Green fluorescent protein (GFP) was used to tag proteins of the mitochondrial matrix, inner, and outer membranes to examine their sorting patterns relative to mtDNA in zygotes of synchronously mated yeast cells in ρ+ × ρ0 crosses. When transiently expressed in one of the haploid parents, each of the marker proteins distributes throughout the fused mitochondrial reticulum of the zygote before equilibration of mtDNA, although the membrane markers equilibrate slower than the matrix marker. A GFP-tagged form of Abf2p, a mtDNA binding protein required for faithful transmission of ρ+ mtDNA in vegetatively growing cells, colocalizes with mtDNA in situ. In zygotes of a ρ+ × ρ+ cross, in which there is little mixing of parental mtDNAs, Abf2p–GFP prelabeled in one parent rapidly equilibrates to most or all of the mtDNA, showing that the mtDNA compartment is accessible to exchange of proteins. In ρ+ × ρ0 crosses, mtDNA is preferentially transmitted to the medial diploid bud, whereas mitochondrial GFP marker proteins distribute throughout the zygote and the bud. In zygotes lacking Abf2p, mtDNA sorting is delayed and preferential sorting is reduced. These findings argue for the existence of a segregation apparatus that directs mtDNA to the emerging bud.

Bibliography

Okamoto, K., Perlman, P. S., & Butow, R. A. (1998). The Sorting of Mitochondrial DNA and Mitochondrial Proteins in Zygotes: Preferential Transmission of Mitochondrial DNA to the Medial Bud. The Journal of Cell Biology, 142(3), 613â623.

Authors 3

Koji Okamoto (first)
Philip S. Perlman (additional)
Ronald A. Butow (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:47 p.m.)
Deposited	2 years, 1 month ago (July 28, 2023, 7:59 p.m.)
Indexed	5 months, 1 week ago (March 27, 2025, 4:59 p.m.)
Issued	27 years ago (Aug. 10, 1998)
Published	27 years ago (Aug. 10, 1998)
Published Online	27 years ago (Aug. 10, 1998)
Published Print	27 years ago (Aug. 10, 1998)

Funders 0

None

BibTeX

@article{Okamoto_1998, title={The Sorting of Mitochondrial DNA and Mitochondrial Proteins in Zygotes: Preferential Transmission of Mitochondrial DNA to the Medial Bud}, volume={142}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.142.3.613}, DOI={10.1083/jcb.142.3.613}, number={3}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Okamoto, Koji and Perlman, Philip S. and Butow, Ronald A.}, year={1998}, month=aug, pages={613–623} }

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