DOI: 10.1083/jcb.142.2.545. Coordination of an Array of Signaling Proteins through Homo- and Heteromeric Interactions Between PDZ Domains and Target Proteins

Coordination of an Array of Signaling Proteins through Homo- and Heteromeric Interactions Between PDZ Domains and Target Proteins

10.1083/jcb.142.2.545

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

The rapid activation and feedback regulation of many G protein signaling cascades raises the possibility that the critical signaling proteins may be tightly coupled. Previous studies show that the PDZ domain containing protein INAD, which functions in Drosophila vision, coordinates a signaling complex by binding directly to the light-sensitive ion channel, TRP, and to phospholipase C (PLC). The INAD signaling complex also includes rhodopsin, protein kinase C (PKC), and calmodulin, though it is not known whether these proteins bind to INAD. In the current work, we show that rhodopsin, calmodulin, and PKC associate with the signaling complex by direct binding to INAD. We also found that a second ion channel, TRPL, bound to INAD. Thus, most of the proteins involved directly in phototransduction appear to bind to INAD. Furthermore, we found that INAD formed homopolymers and the homomultimerization occurred through two PDZ domains. Thus, we propose that the INAD supramolecular complex is a higher order signaling web consisting of an extended network of INAD molecules through which a G protein–coupled cascade is tethered.

Bibliography

Xu, X.-Z. S., Choudhury, A., Li, X., & Montell, C. (1998). Coordination of an Array of Signaling Proteins through Homo- and Heteromeric Interactions Between PDZ Domains and Target Proteins. The Journal of Cell Biology, 142(2), 545â555.

Authors 4

Xian-Zhong Shawn Xu (first)
Atish Choudhury (additional)
Xiaoling Li (additional)
Craig Montell (additional)

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Dates

Type	When
Created	23 years ago (July 26, 2002, 12:47 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 3:53 a.m.)
Indexed	2 days, 22 hours ago (Aug. 23, 2025, 12:59 a.m.)
Issued	27 years ago (July 27, 1998)
Published	27 years ago (July 27, 1998)
Published Online	27 years ago (July 27, 1998)
Published Print	27 years ago (July 27, 1998)

Funders 0

None

BibTeX

@article{Xu_1998, title={Coordination of an Array of Signaling Proteins through Homo- and Heteromeric Interactions Between PDZ Domains and Target Proteins}, volume={142}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.142.2.545}, DOI={10.1083/jcb.142.2.545}, number={2}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Xu, Xian-Zhong Shawn and Choudhury, Atish and Li, Xiaoling and Montell, Craig}, year={1998}, month=jul, pages={545–555} }

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