DOI: 10.1083/jcb.140.3.709. A Three-dimensional Collagen Lattice Activates NF-κB in Human Fibroblasts: Role in Integrin α2 Gene Expression and Tissue Remodeling

A Three-dimensional Collagen Lattice Activates NF-κB in Human Fibroblasts: Role in Integrin α2 Gene Expression and Tissue Remodeling

10.1083/jcb.140.3.709

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

Normal adult human dermal fibroblasts grown in a three-dimensional collagen lattice increase mRNA level of collagen receptor integrin subunit α2 (Xu, J., and R.A.F. Clark. 1996. J. Cell Biol. 132:239– 249.) and DNA binding activity of a nuclear transcription factor, NF-κB (Xu, J., and R.A.F. Clark. 1997. J. Cell Biol. 136:473–483.). Here we present evidence that the collagen lattice induced the nuclear translocation of p50, one member of NF-κB family, and the degradation of an NF-κB inhibitor protein, IκB-α. The inhibition of NF-κB activity by SN50, a peptide inhibitor targeted at nuclear translocation of NF-κB, significantly reduced the induction of integrin α2 mRNA and protein by the collagen lattice. A region located between −549 and −351 bp in the promoter of integrin α2 gene conferred the inducibility by three-dimensional collagen lattice. The presence of either SN50 or IκB-α32, 36, a stable mutant of IκB-α, abrogated this inducibility, indicating that the activation of integrin α2 gene expression was possibly mediated by NF-κB through this region. Although there were three DNA–protein binding complexes forming in this region that are sensitive to the inhibition of NF-κB nuclear translocation, NF-κB was not directly present in the binding complexes. Therefore, an indirect regulatory mechanism by NF-κB in integrin α2 gene expression induced by three-dimensional collagen lattice is suggested. The involvement of NF-κB in reorganization and contraction of three-dimensional collagen lattice, a process that requires the presence of abundant integrin α2β1, was also examined. The inhibition of NF-κB activity by SN50 greatly blocked the contraction, suggesting its critical role in not only the induction of integrin α2 gene expression by three- dimensional collagen lattice, but also α2β1-mediated tissue-remodeling process.

Bibliography

Xu, J., Zutter, M. M., Santoro, S. A., & Clark, R. A. F. (1998). A Three-dimensional Collagen Lattice Activates NF-ÎºB in Human Fibroblasts: Role in Integrin Î±2 Gene Expression and Tissue Remodeling. The Journal of Cell Biology, 140(3), 709â719.

Authors 4

Jiahua Xu (first)
Mary M. Zutter (additional)
Samuel A. Santoro (additional)
Richard A.F. Clark (additional)

References 79 Referenced 89

10.1006/excr.1994.1351 / Exp Cell Res / Platelet-derived growth factor-BB stimulates synthesis of the integrin α2-subunit in diploid fibroblasts by Ahlen (1994)
10.1016/S0092-8674(00)81318-5 / Cell / NF-κB: Ten years after by Baeuerle (1996)
10.1146/annurev.immunol.14.1.649 / Annu Rev Immunol / The NF-κB and IκB proteins: new discoveries and insights by Baldwin (1996)
10.1101/gad.7.11.2064 / Genes Dev / The IκB proteins: multifunctional regulators of Rel/NF-κB transcripion factors by Beg (1993)
10.1101/gad.9.22.2736 / Genes Dev / Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in IκBα-deficient mice by Beg (1995)
10.1073/pnas.90.6.2532 / Proc Natl Acad Sci USA / Mutual regulation of the transcriptional activator NF-κB and its inhibitor, IκB-α by Brown (1993)
{'key': '2023072207310197400_B7', 'first-page': '1239', 'article-title': 'Induction of albumin gene transcription in hepatocytes by extracellular matrix proteins', 'volume': '10', 'author': 'Caron', 'year': '1990', 'journal-title': 'Mol Cell Biol'} / Mol Cell Biol / Induction of albumin gene transcription in hepatocytes by extracellular matrix proteins by Caron (1990)
10.1126/science.2011740 / Science / In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells by Chan (1991)
10.1016/S0021-9258(18)42453-2 / J Biol Chem / Adhesion of vascular cell adhesion molecule 1 and fibronectin. Comparison of α4 β1 and α4 β7 on the human cell line JY by Chan (1992)
10.1073/pnas.91.1.28 / Proc Natl Acad Sci USA / Autoregulation of IκBα activity by Chiao (1994)
{'key': '2023072207310197400_B11', 'first-page': '156', 'article-title': 'Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction', 'volume': '162', 'author': 'Chromczynski', 'year': '1987', 'journal-title': 'Anal Biochem'} / Anal Biochem / Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction by Chromczynski (1987)
10.1016/S0021-9258(19)50271-X / J Biol Chem / Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-rel and related NF-κB proteins in human monocytic THP-1 cells by Cordle (1993)
{'key': '2023072207310197400_B13', 'first-page': '4770', 'article-title': 'A dominant negative protein kinase C ζ subspecies blocks NF-κB activation', 'volume': '13', 'author': 'Diaz-Meco', 'year': '1993', 'journal-title': 'Mol Cell Biol'} / Mol Cell Biol / A dominant negative protein kinase C ζ subspecies blocks NF-κB activation by Diaz-Meco (1993)
10.1002/j.1460-2075.1994.tb06578.x / EMBO (Eur Mol Biol Organ) J / ζ-PKC induces phosphorylation and inactivation of IκB-α in vitro by Diaz-Meco (1994)
{'key': '2023072207310197400_B15', 'first-page': '4405', 'article-title': 'The extracellular matrix coordinately modulates liver transcription factors and hepatocyte morphology', 'volume': '11', 'author': 'DiPersio', 'year': '1991', 'journal-title': 'Mol Cell Biol'} / Mol Cell Biol / The extracellular matrix coordinately modulates liver transcription factors and hepatocyte morphology by DiPersio (1991)
10.1074/jbc.271.5.2443 / J Biol Chem / The roles of integrins and extracellular matrix proteins in the insulin-like growth factor 1-stimulated chemotaxis of human breast cancer cells by Doerr (1996)
{'key': '2023072207310197400_B17', 'first-page': '1290', 'article-title': 'Inhibition of protein kinase C ζ subspecies blocks the activation of an NF-κB-like activity in Xenopus laevisoocytes', 'volume': '13', 'author': 'Dominguez', 'year': '1993', 'journal-title': 'Mol Cell Biol'} / Mol Cell Biol / Inhibition of protein kinase C ζ subspecies blocks the activation of an NF-κB-like activity in Xenopus laevisoocytes by Dominguez (1993)
10.1073/pnas.87.12.4727 / Proc Natl Acad Sci USA / Interaction of an NF-κB-like factor with a site upstream of the c-myc promoter by Duyao (1990)
10.1016/0014-5793(93)80006-G / FEBS (Fed Eur Biochem Soc) Lett / Downregulation of collagen synthesis in fibroblasts within three-dimensional collagen lattices involves transcriptional and posttranscriptional mechanisms by Eckes (1993)
10.1073/pnas.86.24.9906 / Proc Natl Acad Sci USA / The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others by Elices (1989)
10.1016/0092-8674(90)90661-W / Cell / VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site by Elices (1990)
10.1016/S0021-9258(17)46756-1 / J Biol Chem / κB site-dependent induction of gene expression by diverse inducers of nuclear factor κB requires raf-1 by Finco (1993)
10.1128/jvi.70.1.223-231.1996 / J Virol / Protein kinase C-ζ mediates NF-κB activation in human immunodeficiency virus-infected monocytes by Folgueira (1996)
10.1006/excr.1995.1032 / Exp Cell Res / Epidermal growth factor enhancement of HSC-1 human cutaneous squamous carcinoma cell adhesion and migration on type I collagen involves selective up-regulation of α2β1integrin expression by Fujii (1995)
10.1073/pnas.86.24.9936 / Proc Natl Acad Sci USA / Induction of the transcription factor IRF-1 and IFN-κ mRNAs by cytokines and activators of second messenger pathways by Fujita (1989)
10.1083/jcb.134.1.13 / J Cell Biol / Bcl-2 down-regulates the activity of transcription factor NF-κB induced upon apoptosis by Grimm (1996)
10.1083/jcb.124.4.401 / J Cell Biol / Fibroblasts, myofibroblasts, and wound contraction by Grinnell (1994)
{'key': '2023072207310197400_B28', 'first-page': '1500', 'article-title': 'Structure and regulation of the human interferon regulatory factor (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system', 'volume': '14', 'author': 'Harada', 'year': '1994', 'journal-title': 'Mol Cell Biol'} / Mol Cell Biol / Structure and regulation of the human interferon regulatory factor (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system by Harada (1994)
10.1038/365182a0 / Nature / Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB by Henkel (1993)
{'key': '2023072207310197400_B30', 'first-page': '265', 'article-title': 'Activation of NF-κB in murine macrophages by taxol', 'volume': '14', 'author': 'Hwang', 'year': '1995', 'journal-title': 'Cancer Biochem Biophys'} / Cancer Biochem Biophys / Activation of NF-κB in murine macrophages by taxol by Hwang (1995)
10.1016/S0092-8674(00)80153-1 / Cell / Tyrosine phosphorylation of IκB-α activates NF-κB without proteolytic degradation of IκB-α by Imbert (1996)
10.1242/jcs.108.2.595 / J Cell Sci / Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense α2integrin mRNA in mammary cells by Keely (1995)
10.1016/S0021-9258(19)40093-8 / J Biol Chem / α2β1integrins from different cell types show different binding specifications by Kirchhofer (1990)
10.1126/science.1299224 / Science / Ablation of transplanted HTLV-I tax transformed tumors in mice by antisense inhibition of NF-κB by Kitajima (1992)
10.1083/jcb.115.5.1427 / J Cell Biol / Integrin α2β1is upregulated in fibroblasts and highly aggressive melanoma cells in three-dimensional collagen lattices and mediates the reorganization of collagen I fibrils by Klein (1991)
10.1128/MCB.16.5.2341 / Mol Cell Biol / IκBα deficiency results in a sustained NF-κB response and severe widespread dermatitis in mice by Klement (1996)
10.1016/S0092-8674(00)81801-2 / Cell / Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of cdk2 inhibitors by Koyama (1996)
{'key': '2023072207310197400_B38', 'first-page': '1401', 'article-title': 'A potential pathophysiologic role for α2β1integrin in human eye diseases involving vitreoretinal traction', 'volume': '7', 'author': 'Kupper', 'year': '1993', 'journal-title': 'FASEB (Fed Am Soc Exp Biol) J'} / FASEB (Fed Am Soc Exp Biol) J / A potential pathophysiologic role for α2β1integrin in human eye diseases involving vitreoretinal traction by Kupper (1993)
10.1083/jcb.131.6.1903 / J Cell Biol / Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by α1β1 and α2β1integrins by Langholz (1995)
10.1083/jcb.109.5.2455 / J Cell Biol / Endothelial cells use α2β1integrin as a laminin receptor by Languino (1989)
{'key': '2023072207310197400_B41', 'first-page': '1039', 'article-title': 'Differential regulation of the c-myc oncogene promoter by the NF-κB rel family of transcription factors', 'volume': '14', 'author': 'LaRosa', 'year': '1994', 'journal-title': 'Mol Cell Biol'} / Mol Cell Biol / Differential regulation of the c-myc oncogene promoter by the NF-κB rel family of transcription factors by LaRosa (1994)
10.1002/j.1460-2075.1993.tb06197.x / EMBO (Eur Mol Biol Organ) J / Promoter analysis of the gene encoding the IκB-α/MAD3 inhibitor of NF-κBL positive regulation by members of the rel/NF-κB family by LeBail (1993)
10.1016/S0092-8674(00)81842-5 / Cell / Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway by Lee (1997)
10.1128/MCB.16.8.4257 / Mol Cell Biol / Transcriptional induction of the α-1 acid glycoprotein (AGP) gene by synergistic interaction of two alternative activator forms of AGP/enhancer-binding protein (C/EBPb) and NF-κB or Nopp140 by Lee (1996)
10.1073/pnas.90.20.9247 / Proc Natl Acad Sci USA / Raf-1 protein kinase activates the NF-κB transcription factor by dissociating the cytoplasmic NF-κB-IκB complex by Li (1993)
10.1074/jbc.270.27.16189 / J Biol Chem / Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase by Lin (1995)
10.1074/jbc.270.24.14255 / J Biol Chem / Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence by Lin (1995)
{'key': '2023072207310197400_B48', 'first-page': '773', 'article-title': 'Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro', 'volume': '11', 'author': 'Liu', 'year': '1991', 'journal-title': 'Mol Cell Biol'} / Mol Cell Biol / Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro by Liu (1991)
10.1128/MCB.15.3.1737 / Mol Cell Biol / Transcription- independent turnover of IκBα during monocyte adherence: implications for a translational component regulating IκBα/MAD-3 mRNA levels by Lofquist (1995)
10.1038/385540a0 / Nature / MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1 by Malinin (1997)
{'key': '2023072207310197400_B51', 'first-page': '3802', 'article-title': 'Evidence for differential function of the p50 and p65 subunits of NF-κB with a cell adhesion model', 'volume': '13', 'author': 'Narayanan', 'year': '1993', 'journal-title': 'Mol Cell Biol'} / Mol Cell Biol / Evidence for differential function of the p50 and p65 subunits of NF-κB with a cell adhesion model by Narayanan (1993)
10.1016/S0021-9258(17)31895-1 / J Biol Chem / A set of inducible genes expressed by activated human monocytic and endothelial cells contain κB-like sites that specifically bind c-Rel-p65 heterodimers by Parry (1994)
10.1016/S0021-9258(18)47345-0 / J Biol Chem / Fibronectin attachment activates the NF-κB p50/p65 heterodimer in fibroblasts and smooth muscle cells by Qwarnstrom (1994)
10.1074/jbc.270.22.13548 / J Biol Chem / Integrin α2β1is a positive regulator of collagenase (MMP-1) and collagen α1(I) gene expression by Riikonen (1995)
10.1074/jbc.270.1.376 / J Biol Chem / Transforming growth factor-β regulates collagengel contraction by increasing α2β1integrin expression in osteogenic cells by Riikonen (1995)
10.1016/0092-8674(91)90191-Z / Cell / Integrin α2β1(VLA-2) mediates reorganization and contraction of collagen matrices by human cells by Schiro (1991)
10.1091/mbc.3.6.699 / Mol Biol Cell / A novel transcriptional enhancer is involved in the prolactin- and extracellular matrix-dependent regulation of β-casein gene expression by Schmidhauser (1992)
10.1128/MCB.16.8.4231 / Mol Cell Biol / Involvement of the transcription factor NF-κB in tubular morphogenesis of human microvascular endothelial cells by oxidative stress by Shono (1996)
{'key': '2023072207310197400_B59', 'first-page': '1070', 'article-title': 'Dynamic expression of α1β1 and α2β1 integrin receptors by human vascular smooth muscle cells: α2β1integrin is required for chemotaxis across type I collagen-coated membranes', 'volume': '145', 'author': 'Skinner', 'year': '1994', 'journal-title': 'Am J Pathol'} / Am J Pathol / Dynamic expression of α1β1 and α2β1 integrin receptors by human vascular smooth muscle cells: α2β1integrin is required for chemotaxis across type I collagen-coated membranes by Skinner (1994)
10.1182/blood.V82.2.625.625 / Blood / Antisense oligonucleotides to the p65 subunit of NF-κB block CD11β expression and alter adhesion properties of differentiated HL-60 granulocytes by Sokoloski (1993)
10.1083/jcb.120.1.253 / J Cell Biol / Extracellular matrix regulates expression of the TGF-β1 gene by Streuli (1993)
10.1126/science.8096091 / Science / NF-κB controls expression of inhibitor IκBα: evidence for an inducible autoregulatory pathway by Sun (1993)
10.1083/jcb.109.1.397 / J Cell Biol / The primary structure of the VLA-2/collagen receptor α2subunit (platelet GPIa): Homology to other integrins and the presence of a possible collagen-binding domain by Takada (1989)
10.1002/j.1460-2075.1992.tb05042.x / EMBO (Eur Mol Biol Organ) J / The characterization of the promoter of the gene encoding the p50 subunit of NF-κB indicates that it participates in its own regulation by Ten (1992)
{'key': '2023072207310197400_B65', 'first-page': '2335', 'article-title': 'Rearrangement and altered expression of the NFκB-2 gene in human cutaneous T-lymphoma cells', 'volume': '9', 'author': 'Thakur', 'year': '1994', 'journal-title': 'Oncogene'} / Oncogene / Rearrangement and altered expression of the NFκB-2 gene in human cutaneous T-lymphoma cells by Thakur (1994)
10.1002/j.1460-2075.1995.tb07287.x / EMBO (Eur Mol Biol Organ) J / Phosphorylation of human IκB on serine 32 and 36 controls IκB proteolysis and NF-κB activation in response to diverse stimuli by Traenckner (1995)
{'key': '2023072207310197400_B67', 'first-page': '227', 'article-title': 'The NF-κB p65 promoter', 'volume': '6', 'author': 'Ueberla', 'year': '1993', 'journal-title': 'J AIDS Res'} / J AIDS Res / The NF-κB p65 promoter by Ueberla (1993)
10.1126/science.274.5288.784 / Science / TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB by Wang (1996)
10.1002/j.1460-2075.1996.tb00845.x / EMBO (Eur Mol Biol Organ) J / Inhibition of NF-κB/Rel induces apoptosis of murine B cells by Wu (1996)
10.1083/jcb.132.1.239 / J Cell Biol / Extracellular matrix alters PDGF regulation of fibroblast integrins by Xu (1996)
10.1083/jcb.136.2.473 / J Cell Biol / A three-dimensional collagen lattice induces protein kinase C-ζ activity: Role in α2integrin and collagenase mRNA expression by Xu (1997)
10.1083/jcb.134.5.1301 / J Cell Biol / PDGF induction of α2integrin gene expression is mediated by protein kinase C-ζ by Xu (1996)
10.1016/0014-5793(95)00157-5 / FEBS (Fed Eur Biol Soc) Letts / Inhibition of the DNA binding activity of NF-κB by gold compounds in vitro by Yang (1995)
10.1002/j.1460-2075.1995.tb00300.x / EMBO (Eur Mol Biol Organ) J / Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase by Yang (1995)
10.1128/MCB.16.11.6178 / Mol Cell Biol / Sp1 binding plays a critical role in Erb-B2- and v-ras-mediated downregulation of α2-integrin expression in human mammary epithelial cells by Ye (1996)
10.1016/S0092-8674(00)80406-7 / Cell / The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation by Zandi (1997)
10.1016/S0021-9258(17)42373-8 / J Biol Chem / The human α2integrin gene promoter: identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expression by Zutter (1994)
10.1073/pnas.92.16.7411 / Proc Natl Acad Sci USA / Re-expression of the α2β1integrin abrogates the malignant phenotype of breast carcinoma cells by Zutter (1995)
10.1182/blood.V86.8.3006.3006 / Blood / Regulation of α2integrin gene expression in cells with megakaryocytic features: a common theme of three necessary elements by Zutter (1995)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:47 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 3:32 a.m.)
Indexed	2 months ago (July 1, 2025, 9:48 a.m.)
Issued	27 years, 6 months ago (Feb. 9, 1998)
Published	27 years, 6 months ago (Feb. 9, 1998)
Published Online	27 years, 6 months ago (Feb. 9, 1998)
Published Print	27 years, 6 months ago (Feb. 9, 1998)

Funders 0

None

BibTeX

@article{Xu_1998, title={A Three-dimensional Collagen Lattice Activates NF-κB in Human Fibroblasts: Role in Integrin α2 Gene Expression and Tissue Remodeling}, volume={140}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.140.3.709}, DOI={10.1083/jcb.140.3.709}, number={3}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Xu, Jiahua and Zutter, Mary M. and Santoro, Samuel A. and Clark, Richard A.F.}, year={1998}, month=feb, pages={709–719} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        1
      ]
    ],
    "date-time": "2025-07-01T13:48:30Z",
    "timestamp": 1751377710714
  },
  "reference-count": 79,
  "publisher": "Rockefeller University Press",
  "issue": "3",
  "content-domain": {
    "domain": [
      "rupress.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1998,
        2,
        9
      ]
    ]
  },
  "abstract": "<jats:p>Normal adult human dermal fibroblasts grown in a three-dimensional collagen lattice increase mRNA level of collagen receptor integrin subunit \u03b12 (Xu, J., and R.A.F. Clark. 1996. J. Cell Biol. 132:239\u2013 249.) and DNA binding activity of a nuclear transcription factor, NF-\u03baB (Xu, J., and R.A.F. Clark. 1997. J. Cell Biol. 136:473\u2013483.). Here we present evidence that the collagen lattice induced the nuclear translocation of p50, one member of NF-\u03baB family, and the degradation of an NF-\u03baB inhibitor protein, I\u03baB-\u03b1. The inhibition of NF-\u03baB activity by SN50, a peptide inhibitor targeted at nuclear translocation of NF-\u03baB, significantly reduced the induction of integrin \u03b12 mRNA and protein by the collagen lattice. A region located between \u2212549 and \u2212351 bp in the promoter of integrin \u03b12 gene conferred the inducibility by three-dimensional collagen lattice. The presence of either SN50 or I\u03baB-\u03b132, 36, a stable mutant of I\u03baB-\u03b1, abrogated this inducibility, indicating that the activation of integrin \u03b12 gene expression was possibly mediated by NF-\u03baB through this region. Although there were three DNA\u2013protein binding complexes forming in this region that are sensitive to the inhibition of NF-\u03baB nuclear translocation, NF-\u03baB was not directly present in the binding complexes. Therefore, an indirect regulatory mechanism by NF-\u03baB in integrin \u03b12 gene expression induced by three-dimensional collagen lattice is suggested. The involvement of NF-\u03baB in reorganization and contraction of three-dimensional collagen lattice, a process that requires the presence of abundant integrin \u03b12\u03b21, was also examined. The inhibition of NF-\u03baB activity by SN50 greatly blocked the contraction, suggesting its critical role in not only the induction of integrin \u03b12 gene expression by three- dimensional collagen lattice, but also \u03b12\u03b21-mediated tissue-remodeling process.</jats:p>",
  "DOI": "10.1083/jcb.140.3.709",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T16:47:50Z",
    "timestamp": 1027702070000
  },
  "page": "709-719",
  "update-policy": "http://dx.doi.org/10.1083/jcb.crossmarkpolicy",
  "source": "Crossref",
  "is-referenced-by-count": 89,
  "title": "A Three-dimensional Collagen Lattice Activates NF-\u03baB in Human Fibroblasts: Role in Integrin \u03b12 Gene Expression and Tissue Remodeling",
  "prefix": "10.1083",
  "volume": "140",
  "author": [
    {
      "given": "Jiahua",
      "family": "Xu",
      "sequence": "first",
      "affiliation": [
        {
          "name": "*Department of Dermatology, School of Medicine, State University of New York, Stony Brook, New York 11794-8165; and \u2021Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110"
        }
      ]
    },
    {
      "given": "Mary M.",
      "family": "Zutter",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "*Department of Dermatology, School of Medicine, State University of New York, Stony Brook, New York 11794-8165; and \u2021Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110"
        }
      ]
    },
    {
      "given": "Samuel A.",
      "family": "Santoro",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "*Department of Dermatology, School of Medicine, State University of New York, Stony Brook, New York 11794-8165; and \u2021Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110"
        }
      ]
    },
    {
      "given": "Richard A.F.",
      "family": "Clark",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "*Department of Dermatology, School of Medicine, State University of New York, Stony Brook, New York 11794-8165; and \u2021Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110"
        }
      ]
    }
  ],
  "member": "291",
  "published-online": {
    "date-parts": [
      [
        1998,
        2,
        9
      ]
    ]
  },
  "reference": [
    {
      "key": "2023072207310197400_B1",
      "doi-asserted-by": "crossref",
      "first-page": "347",
      "DOI": "10.1006/excr.1994.1351",
      "article-title": "Platelet-derived growth factor-BB stimulates synthesis of the integrin \u03b12-subunit in diploid fibroblasts",
      "volume": "215",
      "author": "Ahlen",
      "year": "1994",
      "journal-title": "Exp Cell Res"
    },
    {
      "key": "2023072207310197400_B2",
      "doi-asserted-by": "crossref",
      "first-page": "13",
      "DOI": "10.1016/S0092-8674(00)81318-5",
      "article-title": "NF-\u03baB: Ten years after",
      "volume": "87",
      "author": "Baeuerle",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "2023072207310197400_B3",
      "doi-asserted-by": "crossref",
      "first-page": "649",
      "DOI": "10.1146/annurev.immunol.14.1.649",
      "article-title": "The NF-\u03baB and I\u03baB proteins: new discoveries and insights",
      "volume": "14",
      "author": "Baldwin",
      "year": "1996",
      "journal-title": "Annu Rev Immunol"
    },
    {
      "key": "2023072207310197400_B4",
      "doi-asserted-by": "crossref",
      "first-page": "2064",
      "DOI": "10.1101/gad.7.11.2064",
      "article-title": "The I\u03baB proteins: multifunctional regulators of Rel/NF-\u03baB transcripion factors",
      "volume": "7",
      "author": "Beg",
      "year": "1993",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2023072207310197400_B5",
      "doi-asserted-by": "crossref",
      "first-page": "2736",
      "DOI": "10.1101/gad.9.22.2736",
      "article-title": "Constitutive NF-\u03baB activation, enhanced granulopoiesis, and neonatal lethality in I\u03baB\u03b1-deficient mice",
      "volume": "9",
      "author": "Beg",
      "year": "1995",
      "journal-title": "Genes Dev"
    },
    {
      "key": "2023072207310197400_B6",
      "doi-asserted-by": "crossref",
      "first-page": "2532",
      "DOI": "10.1073/pnas.90.6.2532",
      "article-title": "Mutual regulation of the transcriptional activator NF-\u03baB and its inhibitor, I\u03baB-\u03b1",
      "volume": "90",
      "author": "Brown",
      "year": "1993",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "2023072207310197400_B7",
      "first-page": "1239",
      "article-title": "Induction of albumin gene transcription in hepatocytes by extracellular matrix proteins",
      "volume": "10",
      "author": "Caron",
      "year": "1990",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "2023072207310197400_B8",
      "doi-asserted-by": "crossref",
      "first-page": "1600",
      "DOI": "10.1126/science.2011740",
      "article-title": "In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells",
      "volume": "251",
      "author": "Chan",
      "year": "1991",
      "journal-title": "Science"
    },
    {
      "key": "2023072207310197400_B9",
      "doi-asserted-by": "crossref",
      "first-page": "8366",
      "DOI": "10.1016/S0021-9258(18)42453-2",
      "article-title": "Adhesion of vascular cell adhesion molecule 1 and fibronectin. Comparison of \u03b14 \u03b21 and \u03b14 \u03b27 on the human cell line JY",
      "volume": "267",
      "author": "Chan",
      "year": "1992",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "2023072207310197400_B10",
      "doi-asserted-by": "crossref",
      "first-page": "28",
      "DOI": "10.1073/pnas.91.1.28",
      "article-title": "Autoregulation of I\u03baB\u03b1 activity",
      "volume": "91",
      "author": "Chiao",
      "year": "1994",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "2023072207310197400_B11",
      "first-page": "156",
      "article-title": "Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction",
      "volume": "162",
      "author": "Chromczynski",
      "year": "1987",
      "journal-title": "Anal Biochem"
    },
    {
      "key": "2023072207310197400_B12",
      "doi-asserted-by": "crossref",
      "first-page": "11803",
      "DOI": "10.1016/S0021-9258(19)50271-X",
      "article-title": "Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-rel and related NF-\u03baB proteins in human monocytic THP-1 cells",
      "volume": "268",
      "author": "Cordle",
      "year": "1993",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "2023072207310197400_B13",
      "first-page": "4770",
      "article-title": "A dominant negative protein kinase C \u03b6 subspecies blocks NF-\u03baB activation",
      "volume": "13",
      "author": "Diaz-Meco",
      "year": "1993",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "2023072207310197400_B14",
      "doi-asserted-by": "crossref",
      "first-page": "2842",
      "DOI": "10.1002/j.1460-2075.1994.tb06578.x",
      "article-title": "\u03b6-PKC induces phosphorylation and inactivation of I\u03baB-\u03b1 in vitro",
      "volume": "13",
      "author": "Diaz-Meco",
      "year": "1994",
      "journal-title": "EMBO (Eur Mol Biol Organ) J"
    },
    {
      "key": "2023072207310197400_B15",
      "first-page": "4405",
      "article-title": "The extracellular matrix coordinately modulates liver transcription factors and hepatocyte morphology",
      "volume": "11",
      "author": "DiPersio",
      "year": "1991",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "2023072207310197400_B16",
      "doi-asserted-by": "crossref",
      "first-page": "2443",
      "DOI": "10.1074/jbc.271.5.2443",
      "article-title": "The roles of integrins and extracellular matrix proteins in the insulin-like growth factor 1-stimulated chemotaxis of human breast cancer cells",
      "volume": "271",
      "author": "Doerr",
      "year": "1996",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "2023072207310197400_B17",
      "first-page": "1290",
      "article-title": "Inhibition of protein kinase C \u03b6 subspecies blocks the activation of an NF-\u03baB-like activity in Xenopus laevisoocytes",
      "volume": "13",
      "author": "Dominguez",
      "year": "1993",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "2023072207310197400_B18",
      "doi-asserted-by": "crossref",
      "first-page": "4727",
      "DOI": "10.1073/pnas.87.12.4727",
      "article-title": "Interaction of an NF-\u03baB-like factor with a site upstream of the c-myc promoter",
      "volume": "87",
      "author": "Duyao",
      "year": "1990",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "2023072207310197400_B19",
      "doi-asserted-by": "crossref",
      "first-page": "129",
      "DOI": "10.1016/0014-5793(93)80006-G",
      "article-title": "Downregulation of collagen synthesis in fibroblasts within three-dimensional collagen lattices involves transcriptional and posttranscriptional mechanisms",
      "volume": "318",
      "author": "Eckes",
      "year": "1993",
      "journal-title": "FEBS (Fed Eur Biochem Soc) Lett"
    },
    {
      "key": "2023072207310197400_B20",
      "doi-asserted-by": "crossref",
      "first-page": "9906",
      "DOI": "10.1073/pnas.86.24.9906",
      "article-title": "The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others",
      "volume": "86",
      "author": "Elices",
      "year": "1989",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "2023072207310197400_B21",
      "doi-asserted-by": "crossref",
      "first-page": "577",
      "DOI": "10.1016/0092-8674(90)90661-W",
      "article-title": "VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site",
      "volume": "60",
      "author": "Elices",
      "year": "1990",
      "journal-title": "Cell"
    },
    {
      "key": "2023072207310197400_B22",
      "doi-asserted-by": "crossref",
      "first-page": "17676",
      "DOI": "10.1016/S0021-9258(17)46756-1",
      "article-title": "\u03baB site-dependent induction of gene expression by diverse inducers of nuclear factor \u03baB requires raf-1",
      "volume": "268",
      "author": "Finco",
      "year": "1993",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "2023072207310197400_B23",
      "doi-asserted-by": "crossref",
      "first-page": "223",
      "DOI": "10.1128/jvi.70.1.223-231.1996",
      "article-title": "Protein kinase C-\u03b6 mediates NF-\u03baB activation in human immunodeficiency virus-infected monocytes",
      "volume": "70",
      "author": "Folgueira",
      "year": "1996",
      "journal-title": "J Virol"
    },
    {
      "key": "2023072207310197400_B24",
      "doi-asserted-by": "crossref",
      "first-page": "261",
      "DOI": "10.1006/excr.1995.1032",
      "article-title": "Epidermal growth factor enhancement of HSC-1 human cutaneous squamous carcinoma cell adhesion and migration on type I collagen involves selective up-regulation of \u03b12\u03b21integrin expression",
      "volume": "216",
      "author": "Fujii",
      "year": "1995",
      "journal-title": "Exp Cell Res"
    },
    {
      "key": "2023072207310197400_B25",
      "doi-asserted-by": "crossref",
      "first-page": "9936",
      "DOI": "10.1073/pnas.86.24.9936",
      "article-title": "Induction of the transcription factor IRF-1 and IFN-\u03ba mRNAs by cytokines and activators of second messenger pathways",
      "volume": "86",
      "author": "Fujita",
      "year": "1989",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "2023072207310197400_B26",
      "doi-asserted-by": "crossref",
      "first-page": "13",
      "DOI": "10.1083/jcb.134.1.13",
      "article-title": "Bcl-2 down-regulates the activity of transcription factor NF-\u03baB induced upon apoptosis",
      "volume": "134",
      "author": "Grimm",
      "year": "1996",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "2023072207310197400_B27",
      "doi-asserted-by": "crossref",
      "first-page": "401",
      "DOI": "10.1083/jcb.124.4.401",
      "article-title": "Fibroblasts, myofibroblasts, and wound contraction",
      "volume": "124",
      "author": "Grinnell",
      "year": "1994",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "2023072207310197400_B28",
      "first-page": "1500",
      "article-title": "Structure and regulation of the human interferon regulatory factor (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system",
      "volume": "14",
      "author": "Harada",
      "year": "1994",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "2023072207310197400_B29",
      "doi-asserted-by": "crossref",
      "first-page": "182",
      "DOI": "10.1038/365182a0",
      "article-title": "Rapid proteolysis of I\u03baB-\u03b1 is necessary for activation of transcription factor NF-\u03baB",
      "volume": "365",
      "author": "Henkel",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "2023072207310197400_B30",
      "first-page": "265",
      "article-title": "Activation of NF-\u03baB in murine macrophages by taxol",
      "volume": "14",
      "author": "Hwang",
      "year": "1995",
      "journal-title": "Cancer Biochem Biophys"
    },
    {
      "key": "2023072207310197400_B31",
      "doi-asserted-by": "crossref",
      "first-page": "787",
      "DOI": "10.1016/S0092-8674(00)80153-1",
      "article-title": "Tyrosine phosphorylation of I\u03baB-\u03b1 activates NF-\u03baB without proteolytic degradation of I\u03baB-\u03b1",
      "volume": "86",
      "author": "Imbert",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "2023072207310197400_B32",
      "doi-asserted-by": "crossref",
      "first-page": "595",
      "DOI": "10.1242/jcs.108.2.595",
      "article-title": "Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense \u03b12integrin mRNA in mammary cells",
      "volume": "108",
      "author": "Keely",
      "year": "1995",
      "journal-title": "J Cell Sci"
    },
    {
      "key": "2023072207310197400_B33",
      "doi-asserted-by": "crossref",
      "first-page": "615",
      "DOI": "10.1016/S0021-9258(19)40093-8",
      "article-title": "\u03b12\u03b21integrins from different cell types show different binding specifications",
      "volume": "265",
      "author": "Kirchhofer",
      "year": "1990",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "2023072207310197400_B34",
      "doi-asserted-by": "crossref",
      "first-page": "1792",
      "DOI": "10.1126/science.1299224",
      "article-title": "Ablation of transplanted HTLV-I tax transformed tumors in mice by antisense inhibition of NF-\u03baB",
      "volume": "258",
      "author": "Kitajima",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "2023072207310197400_B35",
      "doi-asserted-by": "crossref",
      "first-page": "1427",
      "DOI": "10.1083/jcb.115.5.1427",
      "article-title": "Integrin \u03b12\u03b21is upregulated in fibroblasts and highly aggressive melanoma cells in three-dimensional collagen lattices and mediates the reorganization of collagen I fibrils",
      "volume": "115",
      "author": "Klein",
      "year": "1991",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "2023072207310197400_B36",
      "doi-asserted-by": "crossref",
      "first-page": "2341",
      "DOI": "10.1128/MCB.16.5.2341",
      "article-title": "I\u03baB\u03b1 deficiency results in a sustained NF-\u03baB response and severe widespread dermatitis in mice",
      "volume": "16",
      "author": "Klement",
      "year": "1996",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "2023072207310197400_B37",
      "doi-asserted-by": "crossref",
      "first-page": "1069",
      "DOI": "10.1016/S0092-8674(00)81801-2",
      "article-title": "Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of cdk2 inhibitors",
      "volume": "87",
      "author": "Koyama",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "2023072207310197400_B38",
      "first-page": "1401",
      "article-title": "A potential pathophysiologic role for \u03b12\u03b21integrin in human eye diseases involving vitreoretinal traction",
      "volume": "7",
      "author": "Kupper",
      "year": "1993",
      "journal-title": "FASEB (Fed Am Soc Exp Biol) J"
    },
    {
      "key": "2023072207310197400_B39",
      "doi-asserted-by": "crossref",
      "first-page": "1903",
      "DOI": "10.1083/jcb.131.6.1903",
      "article-title": "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by \u03b11\u03b21 and \u03b12\u03b21integrins",
      "volume": "131",
      "author": "Langholz",
      "year": "1995",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "2023072207310197400_B40",
      "doi-asserted-by": "crossref",
      "first-page": "2455",
      "DOI": "10.1083/jcb.109.5.2455",
      "article-title": "Endothelial cells use \u03b12\u03b21integrin as a laminin receptor",
      "volume": "109",
      "author": "Languino",
      "year": "1989",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "2023072207310197400_B41",
      "first-page": "1039",
      "article-title": "Differential regulation of the c-myc oncogene promoter by the NF-\u03baB rel family of transcription factors",
      "volume": "14",
      "author": "LaRosa",
      "year": "1994",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "2023072207310197400_B42",
      "doi-asserted-by": "crossref",
      "first-page": "5043",
      "DOI": "10.1002/j.1460-2075.1993.tb06197.x",
      "article-title": "Promoter analysis of the gene encoding the I\u03baB-\u03b1/MAD3 inhibitor of NF-\u03baBL positive regulation by members of the rel/NF-\u03baB family",
      "volume": "12",
      "author": "LeBail",
      "year": "1993",
      "journal-title": "EMBO (Eur Mol Biol Organ) J"
    },
    {
      "key": "2023072207310197400_B43",
      "doi-asserted-by": "crossref",
      "first-page": "213",
      "DOI": "10.1016/S0092-8674(00)81842-5",
      "article-title": "Activation of the I\u03baB\u03b1 kinase complex by MEKK1, a kinase of the JNK pathway",
      "volume": "88",
      "author": "Lee",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "2023072207310197400_B44",
      "doi-asserted-by": "crossref",
      "first-page": "4257",
      "DOI": "10.1128/MCB.16.8.4257",
      "article-title": "Transcriptional induction of the \u03b1-1 acid glycoprotein (AGP) gene by synergistic interaction of two alternative activator forms of AGP/enhancer-binding protein (C/EBPb) and NF-\u03baB or Nopp140",
      "volume": "16",
      "author": "Lee",
      "year": "1996",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "2023072207310197400_B45",
      "doi-asserted-by": "crossref",
      "first-page": "9247",
      "DOI": "10.1073/pnas.90.20.9247",
      "article-title": "Raf-1 protein kinase activates the NF-\u03baB transcription factor by dissociating the cytoplasmic NF-\u03baB-I\u03baB complex",
      "volume": "90",
      "author": "Li",
      "year": "1993",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "2023072207310197400_B46",
      "doi-asserted-by": "crossref",
      "first-page": "16189",
      "DOI": "10.1074/jbc.270.27.16189",
      "article-title": "Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase",
      "volume": "270",
      "author": "Lin",
      "year": "1995",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "2023072207310197400_B47",
      "doi-asserted-by": "crossref",
      "first-page": "14255",
      "DOI": "10.1074/jbc.270.24.14255",
      "article-title": "Inhibition of nuclear translocation of transcription factor NF-\u03baB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence",
      "volume": "270",
      "author": "Lin",
      "year": "1995",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "2023072207310197400_B48",
      "first-page": "773",
      "article-title": "Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro",
      "volume": "11",
      "author": "Liu",
      "year": "1991",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "2023072207310197400_B49",
      "doi-asserted-by": "crossref",
      "first-page": "1737",
      "DOI": "10.1128/MCB.15.3.1737",
      "article-title": "Transcription- independent turnover of I\u03baB\u03b1 during monocyte adherence: implications for a translational component regulating I\u03baB\u03b1/MAD-3 mRNA levels",
      "volume": "15",
      "author": "Lofquist",
      "year": "1995",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "2023072207310197400_B50",
      "doi-asserted-by": "crossref",
      "first-page": "540",
      "DOI": "10.1038/385540a0",
      "article-title": "MAP3K-related kinase involved in NF-\u03baB induction by TNF, CD95 and IL-1",
      "volume": "385",
      "author": "Malinin",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "2023072207310197400_B51",
      "first-page": "3802",
      "article-title": "Evidence for differential function of the p50 and p65 subunits of NF-\u03baB with a cell adhesion model",
      "volume": "13",
      "author": "Narayanan",
      "year": "1993",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "2023072207310197400_B52",
      "doi-asserted-by": "crossref",
      "first-page": "20823",
      "DOI": "10.1016/S0021-9258(17)31895-1",
      "article-title": "A set of inducible genes expressed by activated human monocytic and endothelial cells contain \u03baB-like sites that specifically bind c-Rel-p65 heterodimers",
      "volume": "269",
      "author": "Parry",
      "year": "1994",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "2023072207310197400_B53",
      "doi-asserted-by": "crossref",
      "first-page": "30765",
      "DOI": "10.1016/S0021-9258(18)47345-0",
      "article-title": "Fibronectin attachment activates the NF-\u03baB p50/p65 heterodimer in fibroblasts and smooth muscle cells",
      "volume": "269",
      "author": "Qwarnstrom",
      "year": "1994",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "2023072207310197400_B54",
      "doi-asserted-by": "crossref",
      "first-page": "13548",
      "DOI": "10.1074/jbc.270.22.13548",
      "article-title": "Integrin \u03b12\u03b21is a positive regulator of collagenase (MMP-1) and collagen \u03b11(I) gene expression",
      "volume": "270",
      "author": "Riikonen",
      "year": "1995",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "2023072207310197400_B55",
      "doi-asserted-by": "crossref",
      "first-page": "376",
      "DOI": "10.1074/jbc.270.1.376",
      "article-title": "Transforming growth factor-\u03b2 regulates collagengel contraction by increasing \u03b12\u03b21integrin expression in osteogenic cells",
      "volume": "270",
      "author": "Riikonen",
      "year": "1995",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "2023072207310197400_B56",
      "doi-asserted-by": "crossref",
      "first-page": "403",
      "DOI": "10.1016/0092-8674(91)90191-Z",
      "article-title": "Integrin \u03b12\u03b21(VLA-2) mediates reorganization and contraction of collagen matrices by human cells",
      "volume": "67",
      "author": "Schiro",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "2023072207310197400_B57",
      "doi-asserted-by": "crossref",
      "first-page": "699",
      "DOI": "10.1091/mbc.3.6.699",
      "article-title": "A novel transcriptional enhancer is involved in the prolactin- and extracellular matrix-dependent regulation of \u03b2-casein gene expression",
      "volume": "3",
      "author": "Schmidhauser",
      "year": "1992",
      "journal-title": "Mol Biol Cell"
    },
    {
      "key": "2023072207310197400_B58",
      "doi-asserted-by": "crossref",
      "first-page": "4231",
      "DOI": "10.1128/MCB.16.8.4231",
      "article-title": "Involvement of the transcription factor NF-\u03baB in tubular morphogenesis of human microvascular endothelial cells by oxidative stress",
      "volume": "16",
      "author": "Shono",
      "year": "1996",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "2023072207310197400_B59",
      "first-page": "1070",
      "article-title": "Dynamic expression of \u03b11\u03b21 and \u03b12\u03b21 integrin receptors by human vascular smooth muscle cells: \u03b12\u03b21integrin is required for chemotaxis across type I collagen-coated membranes",
      "volume": "145",
      "author": "Skinner",
      "year": "1994",
      "journal-title": "Am J Pathol"
    },
    {
      "key": "2023072207310197400_B60",
      "doi-asserted-by": "crossref",
      "first-page": "625",
      "DOI": "10.1182/blood.V82.2.625.625",
      "article-title": "Antisense oligonucleotides to the p65 subunit of NF-\u03baB block CD11\u03b2 expression and alter adhesion properties of differentiated HL-60 granulocytes",
      "volume": "82",
      "author": "Sokoloski",
      "year": "1993",
      "journal-title": "Blood"
    },
    {
      "key": "2023072207310197400_B61",
      "doi-asserted-by": "crossref",
      "first-page": "253",
      "DOI": "10.1083/jcb.120.1.253",
      "article-title": "Extracellular matrix regulates expression of the TGF-\u03b21 gene",
      "volume": "120",
      "author": "Streuli",
      "year": "1993",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "2023072207310197400_B62",
      "doi-asserted-by": "crossref",
      "first-page": "1912",
      "DOI": "10.1126/science.8096091",
      "article-title": "NF-\u03baB controls expression of inhibitor I\u03baB\u03b1: evidence for an inducible autoregulatory pathway",
      "volume": "259",
      "author": "Sun",
      "year": "1993",
      "journal-title": "Science"
    },
    {
      "key": "2023072207310197400_B63",
      "doi-asserted-by": "crossref",
      "first-page": "397",
      "DOI": "10.1083/jcb.109.1.397",
      "article-title": "The primary structure of the VLA-2/collagen receptor \u03b12subunit (platelet GPIa): Homology to other integrins and the presence of a possible collagen-binding domain",
      "volume": "109",
      "author": "Takada",
      "year": "1989",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "2023072207310197400_B64",
      "doi-asserted-by": "crossref",
      "first-page": "195",
      "DOI": "10.1002/j.1460-2075.1992.tb05042.x",
      "article-title": "The characterization of the promoter of the gene encoding the p50 subunit of NF-\u03baB indicates that it participates in its own regulation",
      "volume": "11",
      "author": "Ten",
      "year": "1992",
      "journal-title": "EMBO (Eur Mol Biol Organ) J"
    },
    {
      "key": "2023072207310197400_B65",
      "first-page": "2335",
      "article-title": "Rearrangement and altered expression of the NF\u03baB-2 gene in human cutaneous T-lymphoma cells",
      "volume": "9",
      "author": "Thakur",
      "year": "1994",
      "journal-title": "Oncogene"
    },
    {
      "key": "2023072207310197400_B66",
      "doi-asserted-by": "crossref",
      "first-page": "2876",
      "DOI": "10.1002/j.1460-2075.1995.tb07287.x",
      "article-title": "Phosphorylation of human I\u03baB on serine 32 and 36 controls I\u03baB proteolysis and NF-\u03baB activation in response to diverse stimuli",
      "volume": "14",
      "author": "Traenckner",
      "year": "1995",
      "journal-title": "EMBO (Eur Mol Biol Organ) J"
    },
    {
      "key": "2023072207310197400_B67",
      "first-page": "227",
      "article-title": "The NF-\u03baB p65 promoter",
      "volume": "6",
      "author": "Ueberla",
      "year": "1993",
      "journal-title": "J AIDS Res"
    },
    {
      "key": "2023072207310197400_B68",
      "doi-asserted-by": "crossref",
      "first-page": "784",
      "DOI": "10.1126/science.274.5288.784",
      "article-title": "TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-\u03baB",
      "volume": "274",
      "author": "Wang",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "2023072207310197400_B69",
      "doi-asserted-by": "crossref",
      "first-page": "4682",
      "DOI": "10.1002/j.1460-2075.1996.tb00845.x",
      "article-title": "Inhibition of NF-\u03baB/Rel induces apoptosis of murine B cells",
      "volume": "15",
      "author": "Wu",
      "year": "1996",
      "journal-title": "EMBO (Eur Mol Biol Organ) J"
    },
    {
      "key": "2023072207310197400_B70",
      "doi-asserted-by": "crossref",
      "first-page": "239",
      "DOI": "10.1083/jcb.132.1.239",
      "article-title": "Extracellular matrix alters PDGF regulation of fibroblast integrins",
      "volume": "132",
      "author": "Xu",
      "year": "1996",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "2023072207310197400_B71",
      "doi-asserted-by": "crossref",
      "first-page": "473",
      "DOI": "10.1083/jcb.136.2.473",
      "article-title": "A three-dimensional collagen lattice induces protein kinase C-\u03b6 activity: Role in \u03b12integrin and collagenase mRNA expression",
      "volume": "136",
      "author": "Xu",
      "year": "1997",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "2023072207310197400_B72",
      "doi-asserted-by": "crossref",
      "first-page": "1301",
      "DOI": "10.1083/jcb.134.5.1301",
      "article-title": "PDGF induction of \u03b12integrin gene expression is mediated by protein kinase C-\u03b6",
      "volume": "134",
      "author": "Xu",
      "year": "1996",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "2023072207310197400_B73",
      "doi-asserted-by": "crossref",
      "first-page": "89",
      "DOI": "10.1016/0014-5793(95)00157-5",
      "article-title": "Inhibition of the DNA binding activity of NF-\u03baB by gold compounds in vitro",
      "volume": "361",
      "author": "Yang",
      "year": "1995",
      "journal-title": "FEBS (Fed Eur Biol Soc) Letts"
    },
    {
      "key": "2023072207310197400_B74",
      "doi-asserted-by": "crossref",
      "first-page": "6095",
      "DOI": "10.1002/j.1460-2075.1995.tb00300.x",
      "article-title": "Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase",
      "volume": "14",
      "author": "Yang",
      "year": "1995",
      "journal-title": "EMBO (Eur Mol Biol Organ) J"
    },
    {
      "key": "2023072207310197400_B75",
      "doi-asserted-by": "crossref",
      "first-page": "6178",
      "DOI": "10.1128/MCB.16.11.6178",
      "article-title": "Sp1 binding plays a critical role in Erb-B2- and v-ras-mediated downregulation of \u03b12-integrin expression in human mammary epithelial cells",
      "volume": "16",
      "author": "Ye",
      "year": "1996",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "2023072207310197400_B76",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1016/S0092-8674(00)80406-7",
      "article-title": "The I\u03baB kinase complex (IKK) contains two kinase subunits, IKK\u03b1 and IKK\u03b2, necessary for I\u03baB phosphorylation and NF-\u03baB activation",
      "volume": "91",
      "author": "Zandi",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "2023072207310197400_B77",
      "doi-asserted-by": "crossref",
      "first-page": "463",
      "DOI": "10.1016/S0021-9258(17)42373-8",
      "article-title": "The human \u03b12integrin gene promoter: identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expression",
      "volume": "269",
      "author": "Zutter",
      "year": "1994",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "2023072207310197400_B78",
      "doi-asserted-by": "crossref",
      "first-page": "7411",
      "DOI": "10.1073/pnas.92.16.7411",
      "article-title": "Re-expression of the \u03b12\u03b21integrin abrogates the malignant phenotype of breast carcinoma cells",
      "volume": "92",
      "author": "Zutter",
      "year": "1995",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "2023072207310197400_B79",
      "doi-asserted-by": "crossref",
      "first-page": "3006",
      "DOI": "10.1182/blood.V86.8.3006.3006",
      "article-title": "Regulation of \u03b12integrin gene expression in cells with megakaryocytic features: a common theme of three necessary elements",
      "volume": "86",
      "author": "Zutter",
      "year": "1995",
      "journal-title": "Blood"
    }
  ],
  "container-title": "The Journal of Cell Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://rupress.org/jcb/article-pdf/140/3/709/1489924/12497.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://rupress.org/jcb/article-pdf/140/3/709/1489924/12497.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        7,
        22
      ]
    ],
    "date-time": "2023-07-22T07:32:40Z",
    "timestamp": 1690011160000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://rupress.org/jcb/article/140/3/709/908/A-Three-dimensional-Collagen-Lattice-Activates-NF"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1998,
        2,
        9
      ]
    ]
  },
  "references-count": 79,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          1998,
          2,
          9
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1083/jcb.140.3.709",
  "relation": {},
  "ISSN": [
    "0021-9525",
    "1540-8140"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1998,
        2,
        9
      ]
    ]
  }
}