DOI: 10.1083/jcb.139.2.507. Actinin-associated LIM Protein: Identification of a Domain Interaction between PDZ and Spectrin-like Repeat Motifs

Actinin-associated LIM Protein: Identification of a Domain Interaction between PDZ and Spectrin-like Repeat Motifs

10.1083/jcb.139.2.507

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

PDZ motifs are protein–protein interaction domains that often bind to COOH-terminal peptide sequences. The two PDZ proteins characterized in skeletal muscle, syntrophin and neuronal nitric oxide synthase, occur in the dystrophin complex, suggesting a role for PDZ proteins in muscular dystrophy. Here, we identify actinin-associated LIM protein (ALP), a novel protein in skeletal muscle that contains an NH2-terminal PDZ domain and a COOH-terminal LIM motif. ALP is expressed at high levels only in differentiated skeletal muscle, while an alternatively spliced form occurs at low levels in the heart. ALP is not a component of the dystrophin complex, but occurs in association with α-actinin-2 at the Z lines of myofibers. Biochemical and yeast two-hybrid analyses demonstrate that the PDZ domain of ALP binds to the spectrin-like motifs of α-actinin-2, defining a new mode for PDZ domain interactions. Fine genetic mapping studies demonstrate that ALP occurs on chromosome 4q35, near the heterochromatic locus that is mutated in fascioscapulohumeral muscular dystrophy.

Bibliography

Xia, H., Winokur, S. T., Kuo, W.-L., Altherr, M. R., & Bredt, D. S. (1997). Actinin-associated LIM Protein: Identification of a Domain Interaction between PDZ and Spectrin-like Repeat Motifs. The Journal of Cell Biology, 139(2), 507â515.

Authors 5

Houhui Xia (first)
Sara T. Winokur (additional)
Wen-Lin Kuo (additional)
Michael R. Altherr (additional)
David S. Bredt (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:47 p.m.)
Deposited	2 years, 1 month ago (July 28, 2023, 8:06 p.m.)
Indexed	1 month, 3 weeks ago (July 8, 2025, 7:29 a.m.)
Issued	27 years, 10 months ago (Oct. 20, 1997)
Published	27 years, 10 months ago (Oct. 20, 1997)
Published Online	27 years, 10 months ago (Oct. 20, 1997)
Published Print	27 years, 10 months ago (Oct. 20, 1997)

Funders 0

None

BibTeX

@article{Xia_1997, title={Actinin-associated LIM Protein: Identification of a Domain Interaction between PDZ and Spectrin-like Repeat Motifs}, volume={139}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.139.2.507}, DOI={10.1083/jcb.139.2.507}, number={2}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Xia, Houhui and Winokur, Sara T. and Kuo, Wen-Lin and Altherr, Michael R. and Bredt, David S.}, year={1997}, month=oct, pages={507–515} }

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