DOI: 10.1083/jcb.137.6.1287. Unconventional Myosins in Inner-Ear Sensory Epithelia

Unconventional Myosins in Inner-Ear Sensory Epithelia

10.1083/jcb.137.6.1287

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

To understand how cells differentially use the dozens of myosin isozymes present in each genome, we examined the distribution of four unconventional myosin isozymes in the inner ear, a tissue that is particularly reliant on actin-rich structures and unconventional myosin isozymes. Of the four isozymes, each from a different class, three are expressed in the hair cells of amphibia and mammals. In stereocilia, constructed of cross-linked F-actin filaments, myosin-Iβ is found mostly near stereociliary tips, myosin-VI is largely absent, and myosin-VIIa colocalizes with crosslinks that connect adjacent stereocilia. In the cuticular plate, a meshwork of actin filaments, myosin-Iβ is excluded, myosin-VI is concentrated, and modest amounts of myosin-VIIa are present. These three myosin isozymes are excluded from other actin-rich domains, including the circumferential actin belt and the cortical actin network. A member of a fourth class, myosin-V, is not expressed in hair cells but is present at high levels in afferent nerve cells that innervate hair cells. Substantial amounts of myosins-Iβ, -VI, and -VIIa are located in a pericuticular necklace that is largely free of F-actin, squeezed between (but not associated with) actin of the cuticular plate and the circumferential belt. Our localization results suggest specific functions for three hair-cell myosin isozymes. As suggested previously, myosin-Iβ probably plays a role in adaptation; concentration of myosin-VI in cuticular plates and association with stereociliary rootlets suggest that this isozyme participates in rigidly anchoring stereocilia; and finally, colocalization with cross-links between adjacent stereocilia indicates that myosin-VIIa is required for the structural integrity of hair bundles.

Bibliography

Hasson, T., Gillespie, P. G., Garcia, J. A., MacDonald, R. B., Zhao, Y., Yee, A. G., Mooseker, M. S., & Corey, D. P. (1997). Unconventional Myosins in Inner-Ear Sensory Epithelia. The Journal of Cell Biology, 137(6), 1287â1307.

Authors 8

Tama Hasson (first)
Peter G. Gillespie (additional)
Jesus A. Garcia (additional)
Richard B. MacDonald (additional)
Yi-dong Zhao (additional)
Ann G. Yee (additional)
Mark S. Mooseker (additional)
David P. Corey (additional)

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Dates

Type	When
Created	23 years ago (July 26, 2002, 12:47 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 2:57 a.m.)
Indexed	12 hours, 7 minutes ago (Aug. 24, 2025, 6:56 p.m.)
Issued	28 years, 2 months ago (June 16, 1997)
Published	28 years, 2 months ago (June 16, 1997)
Published Online	28 years, 2 months ago (June 16, 1997)
Published Print	28 years, 2 months ago (June 16, 1997)

Funders 0

None

BibTeX

@article{Hasson_1997, title={Unconventional Myosins in Inner-Ear Sensory Epithelia}, volume={137}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.137.6.1287}, DOI={10.1083/jcb.137.6.1287}, number={6}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Hasson, Tama and Gillespie, Peter G. and Garcia, Jesus A. and MacDonald, Richard B. and Zhao, Yi-dong and Yee, Ann G. and Mooseker, Mark S. and Corey, David P.}, year={1997}, month=jun, pages={1287–1307} }

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  "abstract": "<jats:p>To understand how cells differentially use the dozens of myosin isozymes present in each genome, we examined the distribution of four unconventional myosin isozymes in the inner ear, a tissue that is particularly reliant on actin-rich structures and unconventional myosin isozymes. Of the four isozymes, each from a different class, three are expressed in the hair cells of amphibia and mammals. In stereocilia, constructed of cross-linked F-actin filaments, myosin-I\u03b2 is found mostly near stereociliary tips, myosin-VI is largely absent, and myosin-VIIa colocalizes with crosslinks that connect adjacent stereocilia. In the cuticular plate, a meshwork of actin filaments, myosin-I\u03b2 is excluded, myosin-VI is concentrated, and modest amounts of myosin-VIIa are present. These three myosin isozymes are excluded from other actin-rich domains, including the circumferential actin belt and the cortical actin network. A member of a fourth class, myosin-V, is not expressed in hair cells but is present at high levels in afferent nerve cells that innervate hair cells. Substantial amounts of myosins-I\u03b2, -VI, and -VIIa are located in a pericuticular necklace that is largely free of F-actin, squeezed between (but not associated with) actin of the cuticular plate and the circumferential belt. Our localization results suggest specific functions for three hair-cell myosin isozymes. As suggested previously, myosin-I\u03b2 probably plays a role in adaptation; concentration of myosin-VI in cuticular plates and association with stereociliary rootlets suggest that this isozyme participates in rigidly anchoring stereocilia; and finally, colocalization with cross-links between adjacent stereocilia indicates that myosin-VIIa is required for the structural integrity of hair bundles.</jats:p>",
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