DOI: 10.1083/jcb.136.4.761. A Mouse Cytoplasmic Exoribonuclease (mXRN1p) with Preference for G4 Tetraplex Substrates

A Mouse Cytoplasmic Exoribonuclease (mXRN1p) with Preference for G4 Tetraplex Substrates

10.1083/jcb.136.4.761

Crossref journal-article

Rockefeller University Press

The Journal of Cell Biology (291)

Abstract

Exoribonucleases are important enzymes for the turnover of cellular RNA species. We have isolated the first mammalian cDNA from mouse demonstrated to encode a 5′–3′ exoribonuclease. The structural conservation of the predicted protein and complementation data in Saccharomyces cerevisiae suggest a role in cytoplasmic mRNA turnover and pre-rRNA processing similar to that of the major cytoplasmic exoribonuclease Xrn1p in yeast. Therefore, a key component of the mRNA decay system in S. cerevisiae has been conserved in evolution from yeasts to mammals. The purified mouse protein (mXRN1p) exhibited a novel substrate preference for G4 RNA tetraplex–containing substrates demonstrated in binding and hydrolysis experiments. mXRN1p is the first RNA turnover function that has been localized in the cytoplasm of mammalian cells. mXRN1p was distributed in small granules and was highly enriched in discrete, prominent foci. The specificity of mXRN1p suggests that RNAs containing G4 tetraplex structures may occur in vivo and may have a role in RNA turnover.

Bibliography

Bashkirov, V. I., Scherthan, H., Solinger, J. A., Buerstedde, J.-M., & Heyer, W.-D. (1997). A Mouse Cytoplasmic Exoribonuclease (mXRN1p) with Preference for G4 Tetraplex Substrates. The Journal of Cell Biology, 136(4), 761â773.

Authors 5

Vladimir I. Bashkirov (first)
Harry Scherthan (additional)
Jachen A. Solinger (additional)
Jean-Marie Buerstedde (additional)
Wolf-Dietrich Heyer (additional)

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Dates

Type	When
Created	23 years ago (July 26, 2002, 12:47 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 2:46 a.m.)
Indexed	1 month ago (July 19, 2025, 11:54 p.m.)
Issued	28 years, 6 months ago (Feb. 24, 1997)
Published	28 years, 6 months ago (Feb. 24, 1997)
Published Online	28 years, 6 months ago (Feb. 24, 1997)
Published Print	28 years, 6 months ago (Feb. 24, 1997)

Funders 0

None

BibTeX

@article{Bashkirov_1997, title={A Mouse Cytoplasmic Exoribonuclease (mXRN1p) with Preference for G4 Tetraplex Substrates}, volume={136}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.136.4.761}, DOI={10.1083/jcb.136.4.761}, number={4}, journal={The Journal of Cell Biology}, publisher={Rockefeller University Press}, author={Bashkirov, Vladimir I. and Scherthan, Harry and Solinger, Jachen A. and Buerstedde, Jean-Marie and Heyer, Wolf-Dietrich}, year={1997}, month=feb, pages={761–773} }

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