DOI: 10.1083/jcb.135.6.1879. Regulation of epidermal differentiation by a Distal-less homeodomain gene.

Regulation of epidermal differentiation by a Distal-less homeodomain gene.

10.1083/jcb.135.6.1879

Crossref journal-article

Rockefeller University Press

The Journal of cell biology (291)

Abstract

The Distal-less-related homeodomain gene Dlx3 is expressed in terminally differentiated murine epidermal cells. Ectopic expression of this gene in the basal cell layer of transgenic skin results in a severely abnormal epidermal phenotype and leads to perinatal lethality. The basal cells of affected mice ceased to proliferate, and expressed the profilaggrin and loricrin genes which are normally transcribed only in the latest stages of epidermal differentiation. All suprabasal cell types were diminished and the stratum corneum was reduced to a single layer. These data indicate that Dlx3 misexpression results in transformation of basal cells into more differentiated keratinocytes, suggesting that this homeoprotein is an important regulator of epidermal differentiation.

Bibliography

Morasso, M. I., Markova, N. G., & Sargent, T. D. (1996). Regulation of epidermal differentiation by a Distal-less homeodomain gene. The Journal of Cell Biology, 135(6), 1879â1887.

Authors 3

M I Morasso (first)
N G Markova (additional)
T D Sargent (additional)

References 0 Referenced 106

None

Dates

Type	When
Created	21 years, 3 months ago (May 14, 2004, 9:23 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 4:57 a.m.)
Indexed	4 months, 3 weeks ago (April 6, 2025, 5:42 p.m.)
Issued	28 years, 8 months ago (Dec. 15, 1996)
Published	28 years, 8 months ago (Dec. 15, 1996)
Published Online	28 years, 8 months ago (Dec. 15, 1996)
Published Print	28 years, 8 months ago (Dec. 15, 1996)

Funders 0

None

BibTeX

@article{Morasso_1996, title={Regulation of epidermal differentiation by a Distal-less homeodomain gene.}, volume={135}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.135.6.1879}, DOI={10.1083/jcb.135.6.1879}, number={6}, journal={The Journal of cell biology}, publisher={Rockefeller University Press}, author={Morasso, M I and Markova, N G and Sargent, T D}, year={1996}, month=dec, pages={1879–1887} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        4,
        6
      ]
    ],
    "date-time": "2025-04-06T21:42:24Z",
    "timestamp": 1743975744981
  },
  "reference-count": 0,
  "publisher": "Rockefeller University Press",
  "issue": "6",
  "content-domain": {
    "domain": [
      "rupress.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1996,
        12,
        15
      ]
    ]
  },
  "abstract": "<jats:p>The Distal-less-related homeodomain gene Dlx3 is expressed in terminally differentiated murine epidermal cells. Ectopic expression of this gene in the basal cell layer of transgenic skin results in a severely abnormal epidermal phenotype and leads to perinatal lethality. The basal cells of affected mice ceased to proliferate, and expressed the profilaggrin and loricrin genes which are normally transcribed only in the latest stages of epidermal differentiation. All suprabasal cell types were diminished and the stratum corneum was reduced to a single layer. These data indicate that Dlx3 misexpression results in transformation of basal cells into more differentiated keratinocytes, suggesting that this homeoprotein is an important regulator of epidermal differentiation.</jats:p>",
  "DOI": "10.1083/jcb.135.6.1879",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        5,
        15
      ]
    ],
    "date-time": "2004-05-15T01:23:47Z",
    "timestamp": 1084584227000
  },
  "page": "1879-1887",
  "update-policy": "http://dx.doi.org/10.1083/jcb.crossmarkpolicy",
  "source": "Crossref",
  "is-referenced-by-count": 106,
  "title": "Regulation of epidermal differentiation by a Distal-less homeodomain gene.",
  "prefix": "10.1083",
  "volume": "135",
  "author": [
    {
      "given": "M I",
      "family": "Morasso",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA."
        }
      ]
    },
    {
      "given": "N G",
      "family": "Markova",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA."
        }
      ]
    },
    {
      "given": "T D",
      "family": "Sargent",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA."
        }
      ]
    }
  ],
  "member": "291",
  "published-online": {
    "date-parts": [
      [
        1996,
        12,
        15
      ]
    ]
  },
  "container-title": "The Journal of cell biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://rupress.org/jcb/article-pdf/135/6/1879/1497902/1879.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://rupress.org/jcb/article-pdf/135/6/1879/1497902/1879.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        7,
        22
      ]
    ],
    "date-time": "2023-07-22T08:57:18Z",
    "timestamp": 1690016238000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://rupress.org/jcb/article/135/6/1879/29338/Regulation-of-epidermal-differentiation-by-a"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1996,
        12,
        15
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          1996,
          12,
          15
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1083/jcb.135.6.1879",
  "relation": {},
  "ISSN": [
    "0021-9525",
    "1540-8140"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        1996,
        12,
        15
      ]
    ]
  }
}