DOI: 10.1083/jcb.133.6.1383. The phosphoprotein stathmin is essential for nerve growth factor-stimulated differentiation.

The phosphoprotein stathmin is essential for nerve growth factor-stimulated differentiation.

10.1083/jcb.133.6.1383

Crossref journal-article

Rockefeller University Press

The Journal of cell biology (291)

Abstract

Stathmin is a ubiquitous cytosolic protein which undergoes extensive phosphorylation in response to a variety of external signals. It is highly abundant in developing neurons. The use of antisense oligonucleotides which selectively block stathmin expression has allowed us to study directly its role in rat PC12 cells. We show that stathmin depletion prevents nerve growth factor (NGF)-stimulated differentiation of PC12 cells into sympathetic-like neurons although the expression of several NGF-inducible genes was not affected. Furthermore, we found that stathmin phosphorylation in PC12 cells which is induced by NGF depends on mitogen-activated protein kinase (MAPK) activity. We conclude that stathmin is an essential component of the NGF-induced MAPK signaling pathway and performs a key role during differentiation of developing neurons.

Bibliography

Di Paolo, G., Pellier, V., Catsicas, M., Antonsson, B., Catsicas, S., & Grenningloh, G. (1996). The phosphoprotein stathmin is essential for nerve growth factor-stimulated differentiation. The Journal of Cell Biology, 133(6), 1383â1390.

Authors 6

G Di Paolo (first)
V Pellier (additional)
M Catsicas (additional)
B Antonsson (additional)
S Catsicas (additional)
G Grenningloh (additional)

References 0 Referenced 60

None

Dates

Type	When
Created	21 years, 3 months ago (May 14, 2004, 9:23 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 2:22 a.m.)
Indexed	3 months, 1 week ago (May 20, 2025, 9:14 a.m.)
Issued	29 years, 2 months ago (June 15, 1996)
Published	29 years, 2 months ago (June 15, 1996)
Published Online	29 years, 2 months ago (June 15, 1996)
Published Print	29 years, 2 months ago (June 15, 1996)

Funders 0

None

BibTeX

@article{Di_Paolo_1996, title={The phosphoprotein stathmin is essential for nerve growth factor-stimulated differentiation.}, volume={133}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.133.6.1383}, DOI={10.1083/jcb.133.6.1383}, number={6}, journal={The Journal of cell biology}, publisher={Rockefeller University Press}, author={Di Paolo, G and Pellier, V and Catsicas, M and Antonsson, B and Catsicas, S and Grenningloh, G}, year={1996}, month=jun, pages={1383–1390} }

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