DOI: 10.1083/jcb.131.2.539. Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein.

Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein.

10.1083/jcb.131.2.539

Crossref journal-article

Rockefeller University Press

The Journal of cell biology (291)

Abstract

The role of the latent TGF-beta binding protein (LTBP) is unclear. In cultures of fetal rat calvarial cells, which form mineralized bonelike nodules, both LTBP and the TGF-beta 1 precursor localized to large fibrillar structures in the extracellular matrix. The appearance of these fibrillar structures preceded the appearance of type I collagen fibers. Plasmin treatment abolished the fibrillar staining pattern for LTBP and released a complex containing both LTBP and TGF-beta. Antibodies and antisense oligonucleotides against LTBP inhibited the formation of mineralized bonelike nodules in long-term fetal rat calvarial cultures. Immunohistochemistry of fetal and adult rat bone confirmed a fibrillar staining pattern for LTBP in vivo. These findings, together with the known homology of LTBP to the fibrillin family of proteins, suggest a novel function for LTBP, in addition to its role in matrix storage of latent TGF-beta, as a structural matrix protein that may play a role in bone formation.

Bibliography

Dallas, S. L., Miyazono, K., Skerry, T. M., Mundy, G. R., & Bonewald, L. F. (1995). Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein. The Journal of Cell Biology, 131(2), 539â549.

Authors 5

S L Dallas (first)
K Miyazono (additional)
T M Skerry (additional)
G R Mundy (additional)
L F Bonewald (additional)

References 0 Referenced 220

None

Dates

Type	When
Created	21 years, 3 months ago (May 14, 2004, 9:23 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 2:09 a.m.)
Indexed	1 month ago (July 30, 2025, 10:55 a.m.)
Issued	29 years, 10 months ago (Oct. 15, 1995)
Published	29 years, 10 months ago (Oct. 15, 1995)
Published Online	29 years, 10 months ago (Oct. 15, 1995)
Published Print	29 years, 10 months ago (Oct. 15, 1995)

Funders 0

None

BibTeX

@article{Dallas_1995, title={Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein.}, volume={131}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.131.2.539}, DOI={10.1083/jcb.131.2.539}, number={2}, journal={The Journal of cell biology}, publisher={Rockefeller University Press}, author={Dallas, S L and Miyazono, K and Skerry, T M and Mundy, G R and Bonewald, L F}, year={1995}, month=oct, pages={539–549} }

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