DOI: 10.1083/jcb.127.5.1375. Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

10.1083/jcb.127.5.1375

Crossref journal-article

Rockefeller University Press

The Journal of cell biology (291)

Abstract

Catenins mediate the linkage of classical cadherins with actin microfilaments and are part of a higher order protein structure by which cadherins are connected to other cytoplasmic and transmembrane proteins. The ratio of actin-bound to free cadherin-catenin complex, which varies depending on the type and growth rate of cells, is thought to be altered by cellular signals, such as those associated with mitosis, polarization of cells and growth factors during development. EGF induces an immediate tyrosine phosphorylation of beta-catenin and gamma-catenin (plakoglobin). We show here an association of the EGF-receptor with the cadherin-catenin complex. Using recombinant proteins we demonstrate the interaction of EGF-receptor and beta-catenin in in vitro kinase assays. This interaction is mediated by the evolutionarily conserved central "core" region of beta-catenin. These results suggest that catenins represent an important link between EGF-induced signal transduction and cadherin function.

Bibliography

Hoschuetzky, H., Aberle, H., & Kemler, R. (1994). Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. The Journal of Cell Biology, 127(5), 1375â1380.

Authors 3

H Hoschuetzky (first)
H Aberle (additional)
R Kemler (additional)

References 0 Referenced 574

None

Dates

Type	When
Created	21 years, 3 months ago (May 14, 2004, 8:22 p.m.)
Deposited	2 years, 1 month ago (July 22, 2023, 1:50 a.m.)
Indexed	1 month ago (July 28, 2025, 2:51 a.m.)
Issued	30 years, 8 months ago (Dec. 1, 1994)
Published	30 years, 8 months ago (Dec. 1, 1994)
Published Online	30 years, 8 months ago (Dec. 1, 1994)
Published Print	30 years, 8 months ago (Dec. 1, 1994)

Funders 0

None

BibTeX

@article{Hoschuetzky_1994, title={Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.}, volume={127}, ISSN={1540-8140}, url={http://dx.doi.org/10.1083/jcb.127.5.1375}, DOI={10.1083/jcb.127.5.1375}, number={5}, journal={The Journal of cell biology}, publisher={Rockefeller University Press}, author={Hoschuetzky, H and Aberle, H and Kemler, R}, year={1994}, month=dec, pages={1375–1380} }

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